RES1_SCHPO
ID RES1_SCHPO Reviewed; 637 AA.
AC P33520;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Cell division cycle-related protein res1/sct1;
DE AltName: Full=p72sct1;
GN Name=res1; Synonyms=sct1; ORFNames=SPBC725.16;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF GLU-56.
RX PubMed=7916653; DOI=10.1016/0092-8674(93)90079-6;
RA Caligiuri M., Beach D.;
RT "Sct1 functions in partnership with Cdc10 in a transcription complex that
RT activates cell cycle START and inhibits differentiation.";
RL Cell 72:607-619(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=1464317; DOI=10.1002/j.1460-2075.1992.tb05599.x;
RA Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H.,
RA Okayama H.;
RT "A new cdc gene required for S phase entry of Schizosaccharomyces pombe
RT encodes a protein similar to the cdc 10+ and SWI4 gene products.";
RL EMBO J. 11:4923-4932(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Acts as a positive regulator of the mitotic cell cycle and as
CC a negative regulator of sexual differentiation. May be involved in the
CC transcriptional regulation of the cdc22 and cdt1 genes. Is an integral
CC component of the DSC1-like complex.
CC -!- SUBUNIT: DSC1 contains cdc10 and sct1/res1.
CC -!- INTERACTION:
CC P33520; P36630: cig2; NbExp=3; IntAct=EBI-1149288, EBI-1149212;
CC P33520; P41412: res2; NbExp=2; IntAct=EBI-1149288, EBI-1149177;
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DR EMBL; L09270; AAA35340.1; -; mRNA.
DR EMBL; X68789; CAA48683.1; -; mRNA.
DR EMBL; CU329671; CAA22188.1; -; Genomic_DNA.
DR PIR; A45777; A45777.
DR RefSeq; NP_595496.1; NM_001021407.2.
DR AlphaFoldDB; P33520; -.
DR SMR; P33520; -.
DR BioGRID; 277668; 503.
DR DIP; DIP-210N; -.
DR IntAct; P33520; 3.
DR MINT; P33520; -.
DR STRING; 4896.SPBC725.16.1; -.
DR iPTMnet; P33520; -.
DR MaxQB; P33520; -.
DR PaxDb; P33520; -.
DR PRIDE; P33520; -.
DR EnsemblFungi; SPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
DR GeneID; 2541153; -.
DR KEGG; spo:SPBC725.16; -.
DR PomBase; SPBC725.16; res1.
DR VEuPathDB; FungiDB:SPBC725.16; -.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_009666_3_1_1; -.
DR InParanoid; P33520; -.
DR OMA; AMGNLEM; -.
DR PhylomeDB; P33520; -.
DR PRO; PR:P33520; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0030907; C:MBF transcription complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0033309; C:SBF transcription complex; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:PomBase.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:PomBase.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR029793; Mbp1/Res1/Res2.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR PANTHER; PTHR43828:SF1; PTHR43828:SF1; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF04383; KilA-N; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Cell cycle; DNA-binding; Reference proteome; Repeat.
FT CHAIN 1..637
FT /note="Cell division cycle-related protein res1/sct1"
FT /id="PRO_0000067072"
FT DOMAIN 6..112
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REPEAT 236..265
FT /note="ANK 1"
FT REPEAT 357..386
FT /note="ANK 2"
FT DNA_BIND 37..58
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 114..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 56
FT /note="E->K: Renders the cell independent of cdc10 function
FT for the execution of start."
FT /evidence="ECO:0000269|PubMed:7916653"
SQ SEQUENCE 637 AA; 72442 MW; 91FAEBC78E777A04 CRC64;
MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR RTRILEKFAQ
KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL IEYSGSAFMP MSTFTPQSNR
KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS NNMTSTSRMS GIHDALSLQS DFTRSPDMPS
DSFTGSLHDI KASPFSSNNY AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA
LHWAAAMGNL EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI
CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI INLQDDHGDT
ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS KDMSFPENDD SPLNSKIEDN
LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH QTLPNVFTQL SELSKCHEAS LAEKQLTYNL
AMEALEQTVR ETETCQRLWN ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL
HQLKKYVTYF SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL
VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS
