RESA_GEOKA
ID RESA_GEOKA Reviewed; 174 AA.
AC Q5KXL9;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Thiol-disulfide oxidoreductase ResA {ECO:0000255|HAMAP-Rule:MF_01319};
GN Name=resA {ECO:0000255|HAMAP-Rule:MF_01319}; OrderedLocusNames=GK2282;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: Thiol-disulfide oxidoreductase which is required in disulfide
CC reduction during c-type cytochrome synthesis. May accept reducing
CC equivalents from CcdA, leading to breakage of disulfide bonds in
CC apocytochrome c; following this reduction heme can be covalently
CC attached. {ECO:0000255|HAMAP-Rule:MF_01319}.
CC -!- PATHWAY: Protein modification; cytochrome c assembly.
CC {ECO:0000255|HAMAP-Rule:MF_01319}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01319};
CC Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_01319}.
CC Note=The thioredoxin-like motif is exposed on the outside of the
CC membrane. {ECO:0000255|HAMAP-Rule:MF_01319}.
CC -!- SIMILARITY: Belongs to the thioredoxin family. ResA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01319}.
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DR EMBL; BA000043; BAD76567.1; -; Genomic_DNA.
DR RefSeq; WP_011231764.1; NC_006510.1.
DR AlphaFoldDB; Q5KXL9; -.
DR SMR; Q5KXL9; -.
DR STRING; 235909.GK2282; -.
DR EnsemblBacteria; BAD76567; BAD76567; GK2282.
DR KEGG; gka:GK2282; -.
DR eggNOG; COG0526; Bacteria.
DR HOGENOM; CLU_042529_11_2_9; -.
DR OMA; MIGKPFP; -.
DR UniPathway; UPA00555; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01319; ResA; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR023555; Thiol-dS_OxRdtase_ResA.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00578; AhpC-TSA; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytochrome c-type biogenesis; Disulfide bond; Membrane;
KW Oxidoreductase; Redox-active center; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..174
FT /note="Thiol-disulfide oxidoreductase ResA"
FT /id="PRO_0000308271"
FT TRANSMEM 11..30
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01319"
FT DOMAIN 36..174
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01319"
FT DISULFID 74..77
FT /note="Redox-active"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01319"
SQ SEQUENCE 174 AA; 19858 MW; BA6A19DAA65B3F01 CRC64;
MKKQQRLVMR TAILLVLLAA IGYTIYTNFF TEKTAVAVGS TAPDFVLTDL KGHEHRLSDY
RGKGVFLNFW GTWCKPCERE MPYMNELYPI YKKQGVEILA VNVGEPKLSV EKFAERFGLT
FPIVIDRQDQ VLNAYNVGPL PTTFLIDKNG EVKQIITGTM TKEDIERHLE SIKP