ID   RESA_PLAFN              Reviewed;         760 AA.
AC   P13831;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Ring-infected erythrocyte surface antigen;
DE   Flags: Fragment;
GN   Name=RESA;
OS   Plasmodium falciparum (isolate NF7 / Ghana).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5842;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6085696;
RA   Cowman A.F., Coppel R.L., Saint R.B., Favaloro J., Crewther P.E.,
RA   Stahl H.-D., Bianco A.E., Brown G.V., Anders R.F., Kemp D.J.;
RT   "The ring-infected erythrocyte surface antigen (RESA) polypeptide of
RT   Plasmodium falciparum contains two separate blocks of tandem repeats
RT   encoding antigenic epitopes that are naturally immunogenic in man.";
RL   Mol. Biol. Med. 2:207-221(1984).
CC   -!- FUNCTION: May disrupt the normal intermolecular interactions of the
CC       cytoplasmic domain of band 3 and thereby facilitate the invagination of
CC       the red cell membrane which is necessary for the formation of the
CC       parasitophorous vacuole.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Note=Probably located on the cytoplasmic face of the
CC       membrane where it associates with components of the membrane skeleton.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X05181; CAA28816.1; -; mRNA.
DR   AlphaFoldDB; P13831; -.
DR   SMR; P13831; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 6.10.280.180; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR026894; DnaJ_X.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR019111; PRESA_N.
DR   InterPro; IPR044885; PRESA_N_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF14308; DnaJ-X; 1.
DR   Pfam; PF09687; PRESAN; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Malaria; Membrane.
FT   CHAIN           <1..>760
FT                   /note="Ring-infected erythrocyte surface antigen"
FT                   /id="PRO_0000071160"
FT   DOMAIN          307..375
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          214..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..291
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..717
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..738
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        425
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        559
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        563
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         760
SQ   SEQUENCE   760 AA;  88585 MW;  8D1F28D76AB200FF CRC64;
     EFRYSQYKVQ YDMPKEAYES KWTQCIKLID QGGENLEERL NSQFKNWYRQ KYLNLEEYRR
     LTVLNQIAWK ALSNQIQYSC RKIMNSDISS FKHINELKSL EHRAAKAAEA EMKKRAQKPK
     KKKSRRGWLC CGGGDIETVE PQQEEPVQTV QEQQVNEYGD ILPTLRASIT NSAINYYDTV
     KDGVYLDHET SDALYTDEDL LFDLEKQKYM DMLDTSQEES VEENEEEHTV DDEHVEEHTA
     DDEHVEEPTV ADDEHVEEPT VADEHVEEPT VAEEHVEEPT VAEEHVEEPA SDVQQTSEAA
     PTIEIPDTLY YDILGVGVNA DMNEITERYF KLAENYYPYQ RSGSTVFHNF RKVNEAYQVL
     GDIDKKRWYN KYGYDGIKQV NFMNPSIFYL LSSLEKFKDF TGTPQIVTLL RFFFEKRLSM
     NDLENKSEHL LKFMEQYQKE REAHVSEYLL NILQPCIAGD SKWNVPIITK LEGLKGSRFD
     IPILESLRWI FKHVAKTHLK KSSKSAKKLQ QRTQANKQEL ANINNNLMST LKEYLGSSEQ
     MNSITYNFEN INSNVDNGNQ SKNISDLSYT DQKEILEKIV SYIVDISLYD IENTALNAAE
     QLLSDNSVDE KTLKKRAQSL KKLSSIMERY AGGKRNDKKA KKYDTQDVVG YIMHGISTIN
     KEMKNQNENV PEHVQHNAEA NVEHDAEENV EHDAEENAEE NVEENVEEVE ENVEENVEEN
     VGEKKMRREE KKKRVQEPIK IDEIQVYDII KNEKKKKTEF