ID   RESB_BACSU              Reviewed;         542 AA.
AC   P35161;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cytochrome c biogenesis protein ResB;
GN   Name=resB; Synonyms=ypxB; OrderedLocusNames=BSU23140;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=7934829; DOI=10.1111/j.1365-2958.1993.tb02670.x;
RA   Sorokin A.V., Zumstein E., Azevedo V., Ehrlich S.D., Serror P.;
RT   "The organization of the Bacillus subtilis 168 chromosome region between
RT   the spoVA and serA genetic loci, based on sequence data.";
RL   Mol. Microbiol. 10:385-395(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   GENE NAME.
RX   PubMed=8631715; DOI=10.1128/jb.178.5.1374-1385.1996;
RA   Sun G., Sharkova E., Chesnut R., Birkey S., Duggan M.F., Sorokin A.V.,
RA   Pujic P., Ehrlich S.D., Hulett F.M.;
RT   "Regulators of aerobic and anaerobic respiration in Bacillus subtilis.";
RL   J. Bacteriol. 178:1374-1385(1996).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=10844653; DOI=10.1046/j.1365-2958.2000.01883.x;
RA   Le Brun N.E., Bengtsson J., Hederstedt L.;
RT   "Genes required for cytochrome c synthesis in Bacillus subtilis.";
RL   Mol. Microbiol. 36:638-650(2000).
CC   -!- FUNCTION: Required for the biogenesis of c-type cytochromes.
CC       {ECO:0000269|PubMed:10844653}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene exhibit a lack of
CC       cytochromes c but normal contents of cytochrome a and b. Can sporulate.
CC       {ECO:0000269|PubMed:10844653}.
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DR   EMBL; L09228; AAA67495.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14246.1; -; Genomic_DNA.
DR   PIR; S45557; S45557.
DR   RefSeq; NP_390195.1; NC_000964.3.
DR   RefSeq; WP_003230515.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P35161; -.
DR   IntAct; P35161; 2.
DR   STRING; 224308.BSU23140; -.
DR   PaxDb; P35161; -.
DR   PRIDE; P35161; -.
DR   EnsemblBacteria; CAB14246; CAB14246; BSU_23140.
DR   GeneID; 938961; -.
DR   KEGG; bsu:BSU23140; -.
DR   PATRIC; fig|224308.179.peg.2521; -.
DR   eggNOG; COG1333; Bacteria.
DR   InParanoid; P35161; -.
DR   OMA; AHTNKNW; -.
DR   BioCyc; BSUB:BSU23140-MON; -.
DR   BioCyc; MetaCyc:BSU23140-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR023494; Cyt_c_bgen_Ccs1/CcsB/ResB.
DR   InterPro; IPR007816; ResB-like_domain.
DR   PANTHER; PTHR31566; PTHR31566; 1.
DR   Pfam; PF05140; ResB; 2.
PE   4: Predicted;
KW   Cell membrane; Cytochrome c-type biogenesis; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..542
FT                   /note="Cytochrome c biogenesis protein ResB"
FT                   /id="PRO_0000097253"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   542 AA;  61761 MW;  78A9719B118E3804 CRC64;
     MKQVKCECGH INPVGTVLCE SCGRALQETQ PPLADMRYDG SARRSQTYNK TIIDKIWNFF
     SSVKVGIWLI VITLAASAFG TIFPQEAYLP PGAQADTYYK EQYGTFGQLY YLLGFHHLYG
     SWWYLLLIAS IGISLVICSL DRVIPLYRAL KNQGVRRSPA FLRRQRLFSE TVTVLNGESK
     EKIVTLLKKK HYRIREKEGS ILAEKGRFSR WGPYVNHIGL IIFLIGAMLR FVPGMYVDET
     LWVREGETAA IPGTDGKYYL KNNQFSVETY NSKTEKKVFA DAIDRVGDGR VAKNFQTDAV
     LYKREGKIVY GEKPKLEKVT EEDIRVNQPL RFDSFSVYQV DYKENQLDQM VFQLIDKKTK
     KSFGSLKINL LDPDSVYDLG NGYKVEIASY LPDFYFNQDG EPSTKTKIPN NPAFVFNIIT
     PDKPKGEKSF VAIQETIEGS GNNKYKLKFD HVETKNITGL TVRKDLTLWV LAVGGAIFMI
     GVIQGMYWQH RRIWLHSQDG AVMVAGHTNK NWFGLKKDLA FILADSGLTE PVDQKELIKT
     QK