RESC_BACSU
ID RESC_BACSU Reviewed; 391 AA.
AC P35162;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Cytochrome c biogenesis protein ResC;
GN Name=resC; Synonyms=ypxC; OrderedLocusNames=BSU23130;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=7934829; DOI=10.1111/j.1365-2958.1993.tb02670.x;
RA Sorokin A.V., Zumstein E., Azevedo V., Ehrlich S.D., Serror P.;
RT "The organization of the Bacillus subtilis 168 chromosome region between
RT the spoVA and serA genetic loci, based on sequence data.";
RL Mol. Microbiol. 10:385-395(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO N-TERMINUS.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP GENE NAME.
RX PubMed=8631715; DOI=10.1128/jb.178.5.1374-1385.1996;
RA Sun G., Sharkova E., Chesnut R., Birkey S., Duggan M.F., Sorokin A.V.,
RA Pujic P., Ehrlich S.D., Hulett F.M.;
RT "Regulators of aerobic and anaerobic respiration in Bacillus subtilis.";
RL J. Bacteriol. 178:1374-1385(1996).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168 / BGSC1A1;
RX PubMed=10844653; DOI=10.1046/j.1365-2958.2000.01883.x;
RA Le Brun N.E., Bengtsson J., Hederstedt L.;
RT "Genes required for cytochrome c synthesis in Bacillus subtilis.";
RL Mol. Microbiol. 36:638-650(2000).
RN [6]
RP INTERACTION WITH FLOT, AND SUBCELLULAR LOCATION.
RC STRAIN=168;
RX PubMed=23651456; DOI=10.1111/mmi.12252;
RA Bach J.N., Bramkamp M.;
RT "Flotillins functionally organize the bacterial membrane.";
RL Mol. Microbiol. 88:1205-1217(2013).
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes.
CC {ECO:0000269|PubMed:10844653}.
CC -!- SUBUNIT: Interacts with FloT. {ECO:0000269|PubMed:23651456}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23651456,
CC ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane raft
CC {ECO:0000269|PubMed:23651456}; Multi-pass membrane protein.
CC Note=Present in detergent-resistant membrane (DRM) fractions that may
CC be equivalent to eukaryotic membrane rafts; these rafts include
CC proteins involved in signaling, molecule trafficking and protein
CC secretion. {ECO:0000269|PubMed:23651456}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene exhibit a lack of
CC cytochromes c but normal contents of cytochrome a and b. Can sporulate.
CC {ECO:0000269|PubMed:10844653}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA67496.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; L09228; AAA67496.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL009126; CAB14245.2; -; Genomic_DNA.
DR PIR; S45558; S45558.
DR RefSeq; NP_390194.2; NC_000964.3.
DR RefSeq; WP_004398799.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P35162; -.
DR STRING; 224308.BSU23130; -.
DR PaxDb; P35162; -.
DR PRIDE; P35162; -.
DR EnsemblBacteria; CAB14245; CAB14245; BSU_23130.
DR GeneID; 938962; -.
DR KEGG; bsu:BSU23130; -.
DR PATRIC; fig|224308.179.peg.2520; -.
DR eggNOG; COG0755; Bacteria.
DR InParanoid; P35162; -.
DR OMA; WLVMHVS; -.
DR PhylomeDB; P35162; -.
DR BioCyc; BSUB:BSU23130-MON; -.
DR BioCyc; MetaCyc:BSU23130-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR017562; Cyt_c_biogenesis_CcsA.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR TIGRFAMs; TIGR03144; cytochr_II_ccsB; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytochrome c-type biogenesis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..391
FT /note="Cytochrome c biogenesis protein ResC"
FT /id="PRO_0000201592"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 391 AA; 43691 MW; 2210077D52B8740C CRC64;
MAELSGNFLY AAFLVYLIAV PIFGGAIRGN KDKKGRPNRW ANIGITLSIV GFFCHLGYFI
TRWAASGHAP VSNMFEFTTA FGMMLVLAFI ILYFLYRLPS LGLFTLSIAL LLIAYASMFP
TDISPLIPSL QSNWLYIHVT TAALGQAILA ISFVAGVIFL LKHVDQTKPS KKTFWLEAIM
FILVTTVAFI AITSAFRLAG YEAEFNWVDK SKEKSVMVYE MPALVGPHQG ELLTEGRMEP
LVDLPALFSG RKVNTVIWSF GAGLVLYGAL RLIIRKRISA LLHPLVKNVN LDLVDEVGYR
AVSIGFPIFT LGALIFAMIW AQLAWTRFWG WDPKEVWALI TFLFYAAYLH LRLSRGWHGE
KSAWLAVIGF AIIMFNLIFV NLVLAGLHSY A
