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RESD_BACSU
ID   RESD_BACSU              Reviewed;         240 AA.
AC   P35163;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Transcriptional regulatory protein ResD;
GN   Name=resD; Synonyms=ypxD; OrderedLocusNames=BSU23120;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=7934829; DOI=10.1111/j.1365-2958.1993.tb02670.x;
RA   Sorokin A.V., Zumstein E., Azevedo V., Ehrlich S.D., Serror P.;
RT   "The organization of the Bacillus subtilis 168 chromosome region between
RT   the spoVA and serA genetic loci, based on sequence data.";
RL   Mol. Microbiol. 10:385-395(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 167.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=8631715; DOI=10.1128/jb.178.5.1374-1385.1996;
RA   Sun G., Sharkova E., Chesnut R., Birkey S., Duggan M.F., Sorokin A.V.,
RA   Pujic P., Ehrlich S.D., Hulett F.M.;
RT   "Regulators of aerobic and anaerobic respiration in Bacillus subtilis.";
RL   J. Bacteriol. 178:1374-1385(1996).
RN   [5]
RP   FUNCTION.
RX   PubMed=8682783; DOI=10.1128/jb.178.13.3796-3802.1996;
RA   Nakano M.N., Zuber P., Glaser P., Danchin A., Hulett F.M.;
RT   "Two-component regulatory proteins ResD-ResE are required for
RT   transcriptional activation of fnr upon oxygen limitation in Bacillus
RT   subtilis.";
RL   J. Bacteriol. 178:3796-3802(1996).
RN   [6]
RP   SUBUNIT.
RC   STRAIN=168;
RX   PubMed=21710567; DOI=10.1002/pmic.201000790;
RA   Delumeau O., Lecointe F., Muntel J., Guillot A., Guedon E., Monnet V.,
RA   Hecker M., Becher D., Polard P., Noirot P.;
RT   "The dynamic protein partnership of RNA polymerase in Bacillus subtilis.";
RL   Proteomics 11:2992-3001(2011).
CC   -!- FUNCTION: Member of the two-component regulatory system ResD/ResE.
CC       Required for the expression of resA, ctaA, qcrABC and fnr; activation
CC       role in global regulation of aerobic and anaerobic respiration.
CC       {ECO:0000269|PubMed:8631715, ECO:0000269|PubMed:8682783}.
CC   -!- SUBUNIT: Interacts with the RNA polymerase core.
CC       {ECO:0000269|PubMed:21710567}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by ResE. {ECO:0000305}.
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DR   EMBL; L09228; AAA67497.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14244.2; -; Genomic_DNA.
DR   PIR; G69691; G69691.
DR   RefSeq; NP_390193.2; NC_000964.3.
DR   RefSeq; WP_003246107.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P35163; -.
DR   SMR; P35163; -.
DR   STRING; 224308.BSU23120; -.
DR   jPOST; P35163; -.
DR   PaxDb; P35163; -.
DR   PRIDE; P35163; -.
DR   EnsemblBacteria; CAB14244; CAB14244; BSU_23120.
DR   GeneID; 938960; -.
DR   KEGG; bsu:BSU23120; -.
DR   PATRIC; fig|224308.179.peg.2519; -.
DR   eggNOG; COG0745; Bacteria.
DR   InParanoid; P35163; -.
DR   OMA; NYEFFGD; -.
DR   PhylomeDB; P35163; -.
DR   BioCyc; BSUB:BSU23120-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..240
FT                   /note="Transcriptional regulatory protein ResD"
FT                   /id="PRO_0000081296"
FT   DOMAIN          8..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        137..237
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         57
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   CONFLICT        167
FT                   /note="E -> V (in Ref. 1; AAA67497)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  27515 MW;  931496E9498D8793 CRC64;
     MDQTNETKIL VVDDEARIRR LLRMYLEREN YAIDEAENGD EAIAKGLEAN YDLILLDLMM
     PGTDGIEVCR QIREKKATPI IMLTAKGEEA NRVQGFEAGT DDYIVKPFSP REVVLRVKAL
     LRRASQTSYF NANTPTKNVL VFSHLSIDHD AHRVTADGTE VSLTPKEYEL LYFLAKTPDK
     VYDREKLLKE VWQYEFFGDL RTVDTHVKRL REKLNKVSPE AAKKIVTVWG VGYKFEVGAE
 
 
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