REST_DANRE
ID REST_DANRE Reviewed; 855 AA.
AC Q2EI20;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=RE1-silencing transcription factor;
DE AltName: Full=Neural-restrictive silencer factor;
GN Name=rest; Synonyms=nrsf;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16525062; DOI=10.1523/jneurosci.5037-05.2006;
RA Olguin P., Oteiza P., Gamboa E., Gomez-Skarmeta J.L., Kukuljan M.;
RT "RE-1 silencer of transcription/neural restrictive silencer factor
RT modulates ectodermal patterning during Xenopus development.";
RL J. Neurosci. 26:2820-2829(2006).
CC -!- FUNCTION: Transcriptional repressor which binds neuron-restrictive
CC silencer element (NRSE) and represses neuronal gene transcription in
CC non-neuronal cells. {ECO:0000250|UniProtKB:Q13127}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13127}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q13127}.
CC -!- DOMAIN: The C2H2-type zinc finger 5 is required for nuclear
CC localization. {ECO:0000250|UniProtKB:Q13127}.
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DR EMBL; DQ377344; ABD32118.1; -; mRNA.
DR AlphaFoldDB; Q2EI20; -.
DR SMR; Q2EI20; -.
DR STRING; 7955.ENSDARP00000004965; -.
DR PaxDb; Q2EI20; -.
DR ZFIN; ZDB-GENE-080415-1; rest.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q2EI20; -.
DR PhylomeDB; Q2EI20; -.
DR PRO; PR:Q2EI20; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0021785; P:branchiomotor neuron axon guidance; IMP:ZFIN.
DR GO; GO:0021610; P:facial nerve morphogenesis; IMP:ZFIN.
DR GO; GO:0021754; P:facial nucleus development; IMP:ZFIN.
DR GO; GO:0007626; P:locomotory behavior; IMP:ZFIN.
DR GO; GO:0097475; P:motor neuron migration; IMP:ZFIN.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:ZFIN.
DR GO; GO:0014043; P:negative regulation of neuron maturation; IMP:ZFIN.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:ZFIN.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0042551; P:neuron maturation; IGI:ZFIN.
DR GO; GO:0001764; P:neuron migration; IMP:ZFIN.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0045667; P:regulation of osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IMP:ZFIN.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..855
FT /note="RE1-silencing transcription factor"
FT /id="PRO_0000269550"
FT ZN_FING 141..163
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..258
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 264..286
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..343
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..400
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 818..840
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 172..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 95562 MW; C2C49BC90E4BD41A CRC64;
MSQPVFPTAS GIFLPDLHHD EVSAPQLVML ANVVVSAEAS ASEYSTEGKQ MMELQTVACS
SYSDSEEDDD AVVRYSMDTS EDLYTQQASH IQPEPVLEEI EIVRVGRPPN QTESTENAAS
AEQKRTTLAI LESSRKKKKP FFCKPCQYQG ENEQEFIVHI RTHGTKKMLV VNGGDSDEDL
SADAGPQTSV PNAESAESNS KGVIRCERCG YNTNRFDHYM AHLKHHTKEG EDQRVFKCTI
CAYTTISQYH WKKHLRNHFP SKLFTCSQCS YFSDRKNNYI QHIRTHAGER PFQCIYCEYS
SSQKTHLTRH MRTHSGERPF KCDNCSYLAA NQHEVTRHAR QVHNGPKPLS CPYCQYKTAD
RSNFKKHVEL HVNPRQFLCP VCKYAASKKC NLQYHIKSRH PGCKDISMDV SKVRLRVKRS
DGDDASPNKL TAEQAKIMEE LEDAGPINLS IKKPSKLNAV VETEKSSKKN MDGKANQPQP
NEKKSSSKND PKEKTAKKLK GKTAVKDTEE TQTEDTRVNN KKETKKAVKS AEKALKSRQK
KEKPVKDSSV QQQSDDCEQT QHTPQQNETQ ENRPEKENRS LTEIANAKDC GKVQTKKPCK
KQTKTLKVCG ETQNVEEEEI MRQKAGKRKA ENPAEPKQRI KRTKKKKDSG KPTTSEANQT
NPEVMESESS EANNASKPDD SIDESQNPPV AESRPDVEPP TVSDCPIEKA PAVEDVQRPL
EAEISTAAPD APEVDSGNEM PSPTDSDGAP GFTPTLPLQH KPTDAEDDEG IHSNDGGSDI
SDSASEGSYD SGLMAGAEKL PETPTEERDA SAARLLSHTC IFCDRSFALE MDYRKHLNRH
LVNVYYLEGA AQGGK
