ID   RES_CLOPE               Reviewed;         189 AA.
AC   Q93MD2;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Resolvase;
GN   Name=res; Synonyms=resP; OrderedLocusNames=PCP15;
OS   Clostridium perfringens (strain 13 / Type A).
OG   Plasmid pCP13.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: A likely role for the res protein would be to stabilize pCP13
CC       by reducing the number of plasmid multimers resulting from homologous
CC       recombination.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000305}.
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DR   EMBL; AP003515; BAB62453.1; -; Genomic_DNA.
DR   RefSeq; WP_010968248.1; NC_003042.1.
DR   AlphaFoldDB; Q93MD2; -.
DR   SMR; Q93MD2; -.
DR   EnsemblBacteria; BAB62453; BAB62453; BAB62453.
DR   KEGG; cpe:resP; -.
DR   HOGENOM; CLU_010686_8_1_9; -.
DR   OMA; HLMADST; -.
DR   Proteomes; UP000000818; Plasmid pCP13.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00397; RECOMBINASES_1; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..189
FT                   /note="Resolvase"
FT                   /id="PRO_0000196365"
FT   DOMAIN          1..139
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT   DNA_BIND        165..184
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          130..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ   SEQUENCE   189 AA;  21540 MW;  44923CC509E32B24 CRC64;
     MLVGYARVST EGQSLNRQID MLVDYGLDKR NIYQEKISGT KLRRDQLDKM IEELQEGDTV
     IITDLTRISR STKDLLNIID RIKEKGASIK SLKDTWLDTS GDNPYNSFLL TVMSGLSQLE
     RDLISQRTKE GLRSAKARGR NGGRPSKRND KADTVGLLYR EGYKIVDIVK QTELSRATVY
     RILKDLNLK