ID   RES_CLOPF               Reviewed;         189 AA.
AC   P07945;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Resolvase;
GN   Name=res;
OS   Clostridium perfringens.
OG   Plasmid pIP404.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1502;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CPN50;
RX   PubMed=2901768; DOI=10.1016/0147-619x(88)90052-2;
RA   Garnier T., Cole S.T.;
RT   "Complete nucleotide sequence and genetic organization of the
RT   bacteriocinogenic plasmid, pIP404, from Clostridium perfringens.";
RL   Plasmid 19:134-150(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CPN50;
RX   PubMed=2896291; DOI=10.1111/j.1365-2958.1987.tb01944.x;
RA   Garnier T., Saurin W., Cole S.T.;
RT   "Molecular characterization of the resolvase gene, res, carried by a
RT   multicopy plasmid from Clostridium perfringens: common evolutionary origin
RT   for prokaryotic site-specific recombinases.";
RL   Mol. Microbiol. 1:371-376(1987).
CC   -!- FUNCTION: A likely role for the res protein would be to stabilize
CC       pIP404 by reducing the number of plasmid multimers resulting from
CC       homologous recombination.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000305}.
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DR   EMBL; Y00537; CAA68600.1; -; Genomic_DNA.
DR   EMBL; M32882; AAA98254.1; -; Genomic_DNA.
DR   PIR; S00869; S00869.
DR   RefSeq; NP_040456.1; NC_001388.1.
DR   RefSeq; WP_010889928.1; NZ_MDJF01000004.1.
DR   AlphaFoldDB; P07945; -.
DR   SMR; P07945; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00397; RECOMBINASES_1; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid.
FT   CHAIN           1..189
FT                   /note="Resolvase"
FT                   /id="PRO_0000196366"
FT   DOMAIN          1..139
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT   DNA_BIND        165..184
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          130..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ   SEQUENCE   189 AA;  21428 MW;  B178138A1146DC84 CRC64;
     MLVGYARVST EEQSLNRQID MLVDYGVDKR NIYQEKISGM KPNREQLDKM IDELQEGDTV
     IITDLTRISR STKDLLNIID RIKAKGASIK SIKDTWLDTS SDNPYNSFLL TVMSGLSQLE
     RDLISQRTKE GLKSAKARGR NGGRPSKRND KADTVGLLYR EGYKIVDIVK QTGLSRATVY
     RVLNDLKLK