ID   RES_YERE8               Reviewed;         152 AA.
AC   A1JNH0;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Toxin Res {ECO:0000305|PubMed:30315706};
DE            EC=2.4.2.- {ECO:0000250|UniProtKB:P9WLP9};
GN   Name=res {ECO:0000303|PubMed:30315706}; OrderedLocusNames=YE2116;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
RN   [2]
RP   FUNCTION AS A TOXIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=30315706; DOI=10.1111/mmi.14150;
RA   Skjerning R.B., Senissar M., Winther K.S., Gerdes K., Brodersen D.E.;
RT   "The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell
RT   stasis by degrading NAD+.";
RL   Mol. Microbiol. 111:221-236(2019).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Expression in E.coli inhibits cell growth; bacteriostasis is
CC       neutralized by expression of cognate antitoxin Xre (PubMed:30315706).
CC       Probably depletes intracellular NAD(+) (By similarity).
CC       {ECO:0000250|UniProtKB:Q7N4H9, ECO:0000269|PubMed:30315706}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with cognate antitoxin Xre.
CC       {ECO:0000250|UniProtKB:Q88K57}.
CC   -!- SIMILARITY: Belongs to the MbcT/ParT/Res family. {ECO:0000305}.
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DR   EMBL; AM286415; CAL12186.1; -; Genomic_DNA.
DR   RefSeq; WP_005169553.1; NC_008800.1.
DR   RefSeq; YP_001006356.1; NC_008800.1.
DR   AlphaFoldDB; A1JNH0; -.
DR   SMR; A1JNH0; -.
DR   STRING; 393305.YE2116; -.
DR   EnsemblBacteria; CAL12186; CAL12186; YE2116.
DR   KEGG; yen:YE2116; -.
DR   PATRIC; fig|393305.7.peg.2278; -.
DR   eggNOG; COG5654; Bacteria.
DR   HOGENOM; CLU_133611_0_1_6; -.
DR   OMA; MELWRIS; -.
DR   BioCyc; YENT393305:G13HL-2051-MON; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR014914; RES_dom.
DR   Pfam; PF08808; RES; 1.
DR   SMART; SM00953; RES; 1.
PE   1: Evidence at protein level;
KW   NAD; Nucleotidyltransferase; Toxin-antitoxin system; Transferase.
FT   CHAIN           1..152
FT                   /note="Toxin Res"
FT                   /id="PRO_0000448608"
SQ   SEQUENCE   152 AA;  17223 MW;  2A9C35AAFE9EFF83 CRC64;
     MMLYRIVMRR YLASTWTGYG AETYGGRWNH KGHAAIYLAS SVSLAMLETL VHIQDSSTLS
     EFELFQIEIE DSNIMLLQPQ DWPTNWRSDP APATTMDIGT EWLESESSLG LLVPSTLVPT
     ENNLLLNPRH KSFQTCLSSV QPLSFAFDPR LK