ID   RET2_PIG                Reviewed;         134 AA.
AC   P50121;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Retinol-binding protein 2;
DE   AltName: Full=Cellular retinol-binding protein II;
DE            Short=CRBP-II;
GN   Name=RBP2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Large white X Landrace; TISSUE=Jejunum;
RX   AGRICOLA=IND20415199; DOI=10.1016/0955-2863(93)90110-I;
RA   Perozzi G., Baril D., Murgia C., Kelly D., Begbie R., King T.P.;
RT   "Expression of differentiated functions in the developing porcine small
RT   intestine.";
RL   J. Nutr. Biochem. 4:699-705(1993).
CC   -!- FUNCTION: Intracellular transport of retinol.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; X77639; CAA54729.1; -; mRNA.
DR   PIR; S45378; S45378.
DR   RefSeq; NP_999616.1; NM_214451.1.
DR   AlphaFoldDB; P50121; -.
DR   SMR; P50121; -.
DR   STRING; 9823.ENSSSCP00000012433; -.
DR   PaxDb; P50121; -.
DR   PeptideAtlas; P50121; -.
DR   GeneID; 407611; -.
DR   KEGG; ssc:407611; -.
DR   CTD; 5948; -.
DR   eggNOG; KOG4015; Eukaryota.
DR   InParanoid; P50121; -.
DR   OrthoDB; 1417203at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR   GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00214; FABP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Retinol-binding; Transport; Vitamin A.
FT   CHAIN           1..134
FT                   /note="Retinol-binding protein 2"
FT                   /id="PRO_0000067397"
FT   BINDING         41
FT                   /ligand="all-trans-retinol"
FT                   /ligand_id="ChEBI:CHEBI:17336"
FT                   /evidence="ECO:0000250|UniProtKB:P50120"
FT   BINDING         109
FT                   /ligand="all-trans-retinol"
FT                   /ligand_id="ChEBI:CHEBI:17336"
FT                   /evidence="ECO:0000250|UniProtKB:P50120"
SQ   SEQUENCE   134 AA;  15638 MW;  7701B7EBD5EF61A6 CRC64;
     MTRDQNGTWE MESNDNFEGY MKALDIDFAT RKIAVALTQT KIIEQDGDKF KTKTNSTFRN
     YDLDFTVGVE FDEYTKGLDN RNVKTLIIWE GDALVCVQKG EKENRGWKQW VEGDKLYLEL
     TCGDQVCRQV FKKK