RET4_PANTR
ID RET4_PANTR Reviewed; 201 AA.
AC P61641;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Retinol-binding protein 4;
DE AltName: Full=Plasma retinol-binding protein;
DE Short=PRBP;
DE Short=RBP;
DE Flags: Precursor;
GN Name=RBP4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Maekawa K., Kojima T., Fujiyama A., Hattori M., Sakaki Y.;
RT "Chimpanzee DNA sequence of RP43-36M02, complete sequence.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Retinol-binding protein that mediates retinol transport in
CC blood plasma. Delivers retinol from the liver stores to the peripheral
CC tissues. Transfers the bound all-trans retinol to STRA6, that then
CC facilitates retinol transport across the cell membrane.
CC {ECO:0000250|UniProtKB:P02753}.
CC -!- SUBUNIT: Interacts with TTR. Interaction with TTR prevents its loss by
CC filtration through the kidney glomeruli. Interacts with STRA6.
CC {ECO:0000250|UniProtKB:P02753}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02753}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AB124586; BAD16621.1; -; Genomic_DNA.
DR RefSeq; NP_001038960.1; NM_001045495.1.
DR RefSeq; XP_009457151.1; XM_009458876.2.
DR RefSeq; XP_009457152.1; XM_009458877.2.
DR AlphaFoldDB; P61641; -.
DR BMRB; P61641; -.
DR SMR; P61641; -.
DR STRING; 9598.ENSPTRP00000004830; -.
DR PaxDb; P61641; -.
DR Ensembl; ENSPTRT00000005226; ENSPTRP00000004830; ENSPTRG00000002768.
DR GeneID; 450617; -.
DR KEGG; ptr:450617; -.
DR CTD; 5950; -.
DR VGNC; VGNC:5717; RBP4.
DR eggNOG; ENOG502RXEW; Eukaryota.
DR GeneTree; ENSGT00510000047107; -.
DR HOGENOM; CLU_094618_0_0_1; -.
DR InParanoid; P61641; -.
DR OMA; FATFEDT; -.
DR OrthoDB; 1631943at2759; -.
DR TreeFam; TF331445; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002768; Expressed in liver and 15 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR GO; GO:0019841; F:retinol binding; IBA:GO_Central.
DR GO; GO:0034632; F:retinol transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0006094; P:gluconeogenesis; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IEA:Ensembl.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR GO; GO:0042572; P:retinol metabolic process; IEA:Ensembl.
DR GO; GO:0034633; P:retinol transport; IBA:GO_Central.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR022271; Lipocalin_ApoD.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002449; Retinol-bd/Purpurin.
DR PANTHER; PTHR11873; PTHR11873; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PIRSF; PIRSF036893; Lipocalin_ApoD; 1.
DR PIRSF; PIRSF500204; RBP_purpurin; 1.
DR PRINTS; PR01174; RETINOLBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Methylation; Reference proteome; Retinol-binding; Secreted;
KW Signal; Transport; Vitamin A.
FT SIGNAL 1..18
FT /evidence="ECO:0000250|UniProtKB:P02753"
FT CHAIN 19..201
FT /note="Retinol-binding protein 4"
FT /id="PRO_0000017967"
FT BINDING 116
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P27485"
FT MOD_RES 139
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q00724"
FT DISULFID 22..178
FT /evidence="ECO:0000250|UniProtKB:P02753"
FT DISULFID 88..192
FT /evidence="ECO:0000250|UniProtKB:P02753"
FT DISULFID 138..147
FT /evidence="ECO:0000250|UniProtKB:P02753"
SQ SEQUENCE 201 AA; 23010 MW; 660C6DD8CC9B811A CRC64;
MKWVWALLLL AALGSGRAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP EGLFLQDNIV
AEFSVDETGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED PAKFKMKYWG VASFLQKGND
DHWIVDTDYD TYAVQYSCRL LNLDGTCADS YSFVFSRDPN GLPPEAQKIV RQRQEELCLA
RQYRLIVHNG YCDGRSERNL L
