RET5_BOVIN
ID RET5_BOVIN Reviewed; 135 AA.
AC P82708; A7MBF0;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Retinol-binding protein 5;
DE AltName: Full=Cellular retinol-binding protein III;
DE Short=CRBP-III;
GN Name=RBP5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Kidney;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-43, AND FUNCTION.
RC TISSUE=Kidney;
RX PubMed=11274389; DOI=10.1073/pnas.061455898;
RA Folli C., Calderone V., Ottonello S., Bolchi A., Zanotti G., Stoppini M.,
RA Berni R.;
RT "Identification, retinoid binding and X-ray analysis of a human retinol-
RT binding protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3710-3715(2001).
CC -!- FUNCTION: Intracellular transport of retinol.
CC {ECO:0000269|PubMed:11274389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Kidney.
CC -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC ligands in its interior. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC protein (FABP) family. {ECO:0000305}.
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DR EMBL; BC151528; AAI51529.1; -; mRNA.
DR RefSeq; NP_001094662.1; NM_001101192.2.
DR RefSeq; XP_005207216.1; XM_005207159.3.
DR RefSeq; XP_015326795.1; XM_015471309.1.
DR AlphaFoldDB; P82708; -.
DR SMR; P82708; -.
DR STRING; 9913.ENSBTAP00000010685; -.
DR PaxDb; P82708; -.
DR Ensembl; ENSBTAT00000010685; ENSBTAP00000010685; ENSBTAG00000008127.
DR GeneID; 539418; -.
DR KEGG; bta:539418; -.
DR CTD; 83758; -.
DR VEuPathDB; HostDB:ENSBTAG00000008127; -.
DR VGNC; VGNC:33816; RBP5.
DR eggNOG; KOG4015; Eukaryota.
DR GeneTree; ENSGT00940000162526; -.
DR HOGENOM; CLU_113772_5_1_1; -.
DR InParanoid; P82708; -.
DR OMA; HWLEGDR; -.
DR OrthoDB; 1377380at2759; -.
DR TreeFam; TF316894; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000008127; Expressed in cortex of kidney and 19 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR031270; CRBP-III.
DR InterPro; IPR000463; Fatty_acid-bd.
DR InterPro; IPR031259; ILBP.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11955; PTHR11955; 1.
DR PANTHER; PTHR11955:SF74; PTHR11955:SF74; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR00178; FATTYACIDBP.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome; Retinol-binding;
KW Transport; Vitamin A.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:11274389"
FT CHAIN 2..135
FT /note="Retinol-binding protein 5"
FT /id="PRO_0000067399"
SQ SEQUENCE 135 AA; 15962 MW; 562A10B255659D49 CRC64;
MPPNLTGYYR FVSQKNLEDY LQALNVNMAL RKIALLLKPD KEIDQRGNHM TVKTLSTFRN
YVLEFEVGVE FEEDLRTVDG RKCQTIVTWE EEQLVCVQKG EVPNRGWRLW LEEEMLYQEV
TARDAVCQCV FRKVK
