RET7_HUMAN
ID RET7_HUMAN Reviewed; 134 AA.
AC Q96R05; B2R517; Q5SWJ4;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Retinoid-binding protein 7;
DE AltName: Full=Cellular retinoic acid-binding protein 4;
DE Short=CRABP4;
DE Short=CRBP4;
DE AltName: Full=Cellular retinoic acid-binding protein IV;
DE Short=CRABP-IV;
GN Name=RBP7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS),
RP FUNCTION, CHARACTERIZATION, AND TISSUE SPECIFICITY.
RX PubMed=12177003; DOI=10.1074/jbc.m207124200;
RA Folli C., Calderone V., Ramazzina I., Zanotti G., Berni R.;
RT "Ligand binding and structural analysis of a human putative cellular
RT retinol-binding protein.";
RL J. Biol. Chem. 277:41970-41977(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Guo J.H., She X.Y., Dai F.Y., Yu L.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Intracellular transport of retinol.
CC {ECO:0000269|PubMed:12177003}.
CC -!- INTERACTION:
CC Q96R05; Q9NZQ3-3: NCKIPSD; NbExp=3; IntAct=EBI-2856326, EBI-10963850;
CC Q96R05; Q92569: PIK3R3; NbExp=3; IntAct=EBI-2856326, EBI-79893;
CC Q96R05; Q8WXH5: SOCS4; NbExp=3; IntAct=EBI-2856326, EBI-3942425;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed primarily in kidney, heart and transverse
CC colon. Detected in adult lymph node, appendix, ascending colon, and in
CC fetal heart and spleen. {ECO:0000269|PubMed:12177003}.
CC -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC ligands in its interior.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC protein (FABP) family. {ECO:0000305}.
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DR EMBL; AY145438; AAN61071.1; -; mRNA.
DR EMBL; AF399927; AAK85409.1; -; mRNA.
DR EMBL; AK312027; BAG34964.1; -; mRNA.
DR EMBL; AL603962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471130; EAW71638.1; -; Genomic_DNA.
DR EMBL; BC063013; AAH63013.1; -; mRNA.
DR CCDS; CCDS109.1; -.
DR RefSeq; NP_443192.1; NM_052960.2.
DR PDB; 1LPJ; X-ray; 2.00 A; A=2-134.
DR PDB; 6AT8; X-ray; 1.10 A; A=2-134.
DR PDB; 6E6K; X-ray; 1.30 A; A=2-134.
DR PDBsum; 1LPJ; -.
DR PDBsum; 6AT8; -.
DR PDBsum; 6E6K; -.
DR AlphaFoldDB; Q96R05; -.
DR SMR; Q96R05; -.
DR BioGRID; 125500; 16.
DR IntAct; Q96R05; 8.
DR STRING; 9606.ENSP00000294435; -.
DR DrugBank; DB00162; Vitamin A.
DR DrugCentral; Q96R05; -.
DR BioMuta; RBP7; -.
DR DMDM; 20139582; -.
DR EPD; Q96R05; -.
DR jPOST; Q96R05; -.
DR MassIVE; Q96R05; -.
DR MaxQB; Q96R05; -.
DR PaxDb; Q96R05; -.
DR PeptideAtlas; Q96R05; -.
DR PRIDE; Q96R05; -.
DR ProteomicsDB; 77921; -.
DR Antibodypedia; 27796; 127 antibodies from 20 providers.
DR DNASU; 116362; -.
DR Ensembl; ENST00000294435.8; ENSP00000294435.7; ENSG00000162444.12.
DR GeneID; 116362; -.
DR KEGG; hsa:116362; -.
DR MANE-Select; ENST00000294435.8; ENSP00000294435.7; NM_052960.3; NP_443192.1.
DR UCSC; uc001aqq.4; human.
DR CTD; 116362; -.
DR DisGeNET; 116362; -.
DR GeneCards; RBP7; -.
DR HGNC; HGNC:30316; RBP7.
DR HPA; ENSG00000162444; Group enriched (adipose tissue, breast, lymphoid tissue).
DR MIM; 608604; gene.
DR neXtProt; NX_Q96R05; -.
DR OpenTargets; ENSG00000162444; -.
DR PharmGKB; PA134988307; -.
DR VEuPathDB; HostDB:ENSG00000162444; -.
DR eggNOG; KOG4015; Eukaryota.
DR GeneTree; ENSGT00940000162218; -.
DR HOGENOM; CLU_113772_5_1_1; -.
DR InParanoid; Q96R05; -.
DR OMA; FYIHTTS; -.
DR OrthoDB; 1417203at2759; -.
DR PhylomeDB; Q96R05; -.
DR TreeFam; TF316894; -.
DR PathwayCommons; Q96R05; -.
DR SignaLink; Q96R05; -.
DR BioGRID-ORCS; 116362; 11 hits in 1061 CRISPR screens.
DR ChiTaRS; RBP7; human.
DR EvolutionaryTrace; Q96R05; -.
DR GenomeRNAi; 116362; -.
DR Pharos; Q96R05; Tbio.
DR PRO; PR:Q96R05; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96R05; protein.
DR Bgee; ENSG00000162444; Expressed in adipose tissue of abdominal region and 170 other tissues.
DR ExpressionAtlas; Q96R05; baseline and differential.
DR Genevisible; Q96R05; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR000463; Fatty_acid-bd.
DR InterPro; IPR031259; ILBP.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11955; PTHR11955; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR00178; FATTYACIDBP.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00214; FABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Retinol-binding; Transport;
KW Vitamin A.
FT CHAIN 1..134
FT /note="Retinoid-binding protein 7"
FT /id="PRO_0000067403"
FT STRAND 7..15
FT /evidence="ECO:0007829|PDB:6AT8"
FT HELIX 17..24
FT /evidence="ECO:0007829|PDB:6AT8"
FT HELIX 28..36
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 40..46
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 49..55
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 60..66
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 71..73
FT /evidence="ECO:0007829|PDB:6AT8"
FT TURN 76..79
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 83..90
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 93..104
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 106..112
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 115..122
FT /evidence="ECO:0007829|PDB:6AT8"
FT STRAND 125..133
FT /evidence="ECO:0007829|PDB:6AT8"
SQ SEQUENCE 134 AA; 15536 MW; B152C8B3D95B20BD CRC64;
MPADLSGTWT LLSSDNFEGY MLALGIDFAT RKIAKLLKPQ KVIEQNGDSF TIHTNSSLRN
YFVKFKVGEE FDEDNRGLDN RKCKSLVIWD NDRLTCIQKG EKKNRGWTHW IEGDKLHLEM
FCEGQVCKQT FQRA
