RETIN_DROME
ID RETIN_DROME Reviewed; 191 AA.
AC Q9VV36; Q8SYA5; Q95TE5; Q9N2Q4;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Retinin {ECO:0000303|PubMed:18828839};
DE Flags: Precursor;
GN Name=retinin {ECO:0000303|PubMed:18828839,
GN ECO:0000312|FlyBase:FBgn0040074};
GN ORFNames=CG13057 {ECO:0000312|FlyBase:FBgn0040074};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|EMBL:AAF29538.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=2105491; DOI=10.1073/pnas.87.3.1008;
RA Hyde D.R., Mecklenburg K.L., Pollock J.A., Vihtelic T.S., Benzer S.;
RT "Twenty Drosophila visual system cDNA clones: one is a homolog of human
RT arrestin.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:1008-1012(1990).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAL13351.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL13351.1};
RC TISSUE=Head {ECO:0000312|EMBL:AAL13351.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000312|EMBL:ABF85738.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305}
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=18828839; DOI=10.1111/j.1365-2583.2008.00822.x;
RA Kim E., Choi Y., Lee S., Seo Y., Yoon J., Baek K.;
RT "Characterization of the Drosophila melanogaster retinin gene encoding a
RT cornea-specific protein.";
RL Insect Mol. Biol. 17:537-543(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18828839}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in cornea (at protein level)
CC (PubMed:18828839). Detected in retina and cortex (PubMed:2105491).
CC {ECO:0000269|PubMed:18828839, ECO:0000269|PubMed:2105491}.
CC -!- DEVELOPMENTAL STAGE: Detected from late pupal stage onwards.
CC {ECO:0000269|PubMed:18828839, ECO:0000269|PubMed:2105491}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:18828839}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown has no visible phenotype.
CC {ECO:0000269|PubMed:18828839}.
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DR EMBL; AF220361; AAF29538.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF49486.2; -; Genomic_DNA.
DR EMBL; AY059445; AAL13351.1; -; mRNA.
DR EMBL; AY071682; AAL49304.1; -; mRNA.
DR EMBL; BT025838; ABF85738.1; -; mRNA.
DR RefSeq; NP_524995.2; NM_080256.4.
DR AlphaFoldDB; Q9VV36; -.
DR STRING; 7227.FBpp0075134; -.
DR PaxDb; Q9VV36; -.
DR DNASU; 53564; -.
DR EnsemblMetazoa; FBtr0075375; FBpp0075134; FBgn0040074.
DR GeneID; 53564; -.
DR KEGG; dme:Dmel_CG13057; -.
DR UCSC; CG13057-RA; d. melanogaster.
DR CTD; 53564; -.
DR FlyBase; FBgn0040074; retinin.
DR VEuPathDB; VectorBase:FBgn0040074; -.
DR eggNOG; KOG3944; Eukaryota.
DR GeneTree; ENSGT00930000151963; -.
DR HOGENOM; CLU_1397697_0_0_1; -.
DR InParanoid; Q9VV36; -.
DR OMA; QTIVHDH; -.
DR OrthoDB; 1423139at2759; -.
DR PhylomeDB; Q9VV36; -.
DR BioGRID-ORCS; 53564; 0 hits in 1 CRISPR screen.
DR ChiTaRS; retinin; fly.
DR GenomeRNAi; 53564; -.
DR PRO; PR:Q9VV36; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0040074; Expressed in insect adult head and 10 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0005212; F:structural constituent of eye lens; IDA:FlyBase.
DR InterPro; IPR007614; Retinin_C.
DR PANTHER; PTHR34931; PTHR34931; 1.
DR Pfam; PF04527; Retinin_C; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..191
FT /note="Retinin"
FT /evidence="ECO:0000255"
FT /id="PRO_5008974705"
FT REGION 52..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 46
FT /note="Missing (in Ref. 4; AAL49304)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="S -> A (in Ref. 1; AAF29538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 191 AA; 20004 MW; 0A6880CC1CCF3CDD CRC64;
MSRLFLPVLA IVLVSIGASH TASLEWPSNL VALSSVKSSQ LLPIASEDSV ELADGSSGSV
SSSAAQPEDQ SQEEAEEQQV SSASSGSADP ISGRLVSAGI PVSVPLPLIL AARNGLRTVL
TIQEPAVAKV GEVVQHVPTA VSHQTQTVVH DHRRLVTPIV APAVRTTQVI RQQPPLLWSV
ASDPRVVLIR N
