ID   RETM_AEDAE              Reviewed;         646 AA.
AC   Q16KN5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Protein real-time;
GN   Name=retm {ECO:0000250|UniProtKB:Q9VMD6}; ORFNames=AAEL012929;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT34866.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9VMD6}.
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DR   EMBL; CH477949; EAT34866.1; -; Genomic_DNA.
DR   RefSeq; XP_001663116.1; XM_001663066.1.
DR   AlphaFoldDB; Q16KN5; -.
DR   SMR; Q16KN5; -.
DR   STRING; 7159.AAEL012929-PA; -.
DR   VEuPathDB; VectorBase:AAEL012929; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_023840_0_0_1; -.
DR   InParanoid; Q16KN5; -.
DR   OMA; NAEWTCF; -.
DR   OrthoDB; 1133487at2759; -.
DR   PhylomeDB; Q16KN5; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..646
FT                   /note="Protein real-time"
FT                   /id="PRO_0000312682"
FT   DOMAIN          2..175
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT   DOMAIN          294..471
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          499..646
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   646 AA;  74377 MW;  C9773F370A181413 CRC64;
     MVQKYESPVR IYKYPFELVM AAYERRFPTC PQMPIVLDCE IIDDAETDNG AKRETKRRCK
     LAVDAPYLFK KIIGIDVAYF IQTNFLDLKT RTLNIEAINE TFSSRIEIFE KCRYYAHPEN
     PDWTCFDQVA TLDIKNFFGF EHSMEKMGMK QYSQTTQKGK EIIEYFINEL KKEGISHVDR
     WKEDETTEPA ATATTTVSIS SEKPPLTRDN SILDADYIAT YLGQLSPLQE SKLVQFRKKI
     EETNHEGKVP DYQTLLRFLR ARDFSIEKAA SMLQESLQWR EEHRIDDILG EYKTPVVVEK
     YFPGGWHHHD KDGRPLYILR LGNMDVKGLL KSVGEDELLK LTLHICEEGL KLMKEATKLF
     GKPIWNWCLL VDLDGLSMRH LWRPGVKALL RIIETVEKNY PETMGRVLIV RAPRVFPVLW
     TIVSAFIDEN TRSKFLFFGG PDCLHIEDGL EHYIPTEKIP SFLGGSCITM IHEGGLIPKH
     LYKSESVEEH NGVPHGHEHH GLYKSVDLKP GQMFELVIKN TDPKSVLTWD IDVLKNDILF
     ALYRTDKDLE QSFNDSFSSV FDNADMKEGV HYTRLEEKVR CKPKEGVQGS HEMATAGTYV
     LQWMCPPSCD GPAQLMYFHE ILSSANYKGS MTSLQSGFSS NSLQSR