RETNA_MOUSE
ID RETNA_MOUSE Reviewed; 111 AA.
AC Q9EP95; Q9D8Y4;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Resistin-like alpha;
DE AltName: Full=Cysteine-rich secreted protein A12-gamma;
DE AltName: Full=Cysteine-rich secreted protein FIZZ1;
DE AltName: Full=Hypoxia-induced mitogenic factor;
DE AltName: Full=Parasite-induced macrophage novel gene 1 protein;
DE AltName: Full=RELMalpha;
DE Flags: Precursor;
GN Name=Retnla; Synonyms=Fizz1, Himf, Pmng1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10921885; DOI=10.1093/emboj/19.15.4046;
RA Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W.,
RA Nelson C., Lowman H.B., Wright B.D., Skelton N.J., Frantz G.D., Tumas D.B.,
RA Peale F.V. Jr., Shelton D.L., Hebert C.C.;
RT "FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary
RT inflammation, defines a new gene family.";
RL EMBO J. 19:4046-4055(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11209052; DOI=10.1073/pnas.98.2.502;
RA Steppan C.M., Brown E.J., Wright C.M., Bhat S., Banerjee R.R., Dai C.Y.,
RA Enders G.H., Silberg D.G., Wen X., Wu G.D., Lazar M.A.;
RT "A family of tissue-specific resistin-like molecules.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:502-506(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Loke P., Nair M.G., Giuliano D.B., Allen J.E.;
RT "PMNG1/FIZZ1 is an IL-4 dependent gene expressed by alternatively activated
RT macrophages that are recruited by a Th2 inducing nematode parasite.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rajala M.W., Scherer P.E.;
RT "Identification of a novel cysteine-rich secreted A12-alpha related
RT protein.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [6]
RP SUBUNIT.
RX PubMed=11358969; DOI=10.1074/jbc.m103109200;
RA Banerjee R.R., Lazar M.A.;
RT "Dimerization of resistin and resistin-like molecules is determined by a
RT single cysteine.";
RL J. Biol. Chem. 276:25970-25973(2001).
RN [7]
RP FUNCTION.
RX PubMed=20582166; DOI=10.1371/journal.pone.0011251;
RA Angelini D.J., Su Q., Kolosova I.A., Fan C., Skinner J.T., Yamaji-Kegan K.,
RA Collector M., Sharkis S.J., Johns R.A.;
RT "Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone
RT marrow-derived cells to the murine pulmonary vasculature.";
RL PLoS ONE 5:E11251-E11251(2010).
CC -!- FUNCTION: Probable hormone. Plays a role in pulmonary vascular
CC remodeling. {ECO:0000269|PubMed:20582166}.
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:11358969}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highest levels in adipose tissue.
CC -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB25104.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF205951; AAG02143.1; -; mRNA.
DR EMBL; AF323082; AAG59825.1; -; mRNA.
DR EMBL; AF316397; AAG41427.1; -; mRNA.
DR EMBL; AF290872; AAK83104.1; -; mRNA.
DR EMBL; AK007553; BAB25104.1; ALT_INIT; mRNA.
DR CCDS; CCDS49864.2; -.
DR RefSeq; NP_065255.2; NM_020509.3.
DR AlphaFoldDB; Q9EP95; -.
DR SMR; Q9EP95; -.
DR STRING; 10090.ENSMUSP00000023329; -.
DR TCDB; 9.B.329.1.1; the resistin-like molecule (relm) family.
DR MaxQB; Q9EP95; -.
DR PaxDb; Q9EP95; -.
DR PeptideAtlas; Q9EP95; -.
DR PRIDE; Q9EP95; -.
DR ProteomicsDB; 253221; -.
DR Ensembl; ENSMUST00000238847; ENSMUSP00000159097; ENSMUSG00000061100.
DR GeneID; 57262; -.
DR KEGG; mmu:57262; -.
DR CTD; 57262; -.
DR MGI; MGI:1888504; Retnla.
DR VEuPathDB; HostDB:ENSMUSG00000061100; -.
DR eggNOG; ENOG502RTZZ; Eukaryota.
DR GeneTree; ENSGT00390000016177; -.
DR InParanoid; Q9EP95; -.
DR OMA; CHCLCPV; -.
DR OrthoDB; 1541877at2759; -.
DR PhylomeDB; Q9EP95; -.
DR BioGRID-ORCS; 57262; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Retnla; mouse.
DR PRO; PR:Q9EP95; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9EP95; protein.
DR Bgee; ENSMUSG00000061100; Expressed in left lung lobe and 82 other tissues.
DR ExpressionAtlas; Q9EP95; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd16333; RELM; 1.
DR Gene3D; 2.60.40.4230; -; 1.
DR InterPro; IPR009714; RELM.
DR InterPro; IPR036262; Resistin-like_sf.
DR PANTHER; PTHR21101; PTHR21101; 1.
DR Pfam; PF06954; Resistin; 1.
DR SUPFAM; SSF111423; SSF111423; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..111
FT /note="Resistin-like alpha"
FT /id="PRO_0000030343"
FT DISULFID 55..108
FT /evidence="ECO:0000250"
FT DISULFID 67..107
FT /evidence="ECO:0000250"
FT DISULFID 76..93
FT /evidence="ECO:0000250"
FT DISULFID 78..95
FT /evidence="ECO:0000250"
FT DISULFID 82..97
FT /evidence="ECO:0000250"
SQ SEQUENCE 111 AA; 11936 MW; 6920F4AD1BF1B0E1 CRC64;
MKTTTCSLLI CISLLQLMVP VNTDETIEII VENKVKELLA NPANYPSTVT KTLSCTSVKT
MNRWASCPAG MTATGCACGF ACGSWEIQSG DTCNCLCLLV DWTTARCCQL S
