ID   RETNA_RAT               Reviewed;         111 AA.
AC   Q99P85;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Resistin-like alpha;
DE   AltName: Full=Cysteine-rich secreted protein FIZZ1;
DE   AltName: Full=RELMalpha;
DE   Flags: Precursor;
GN   Name=Retnla; Synonyms=Fizz1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11209052; DOI=10.1073/pnas.98.2.502;
RA   Steppan C.M., Brown E.J., Wright C.M., Bhat S., Banerjee R.R., Dai C.Y.,
RA   Enders G.H., Silberg D.G., Wen X., Wu G.D., Lazar M.A.;
RT   "A family of tissue-specific resistin-like molecules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:502-506(2001).
CC   -!- FUNCTION: Probable hormone. Plays a role in pulmonary vascular
CC       remodeling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highest levels in adipose tissue.
CC   -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF323085; AAG59828.1; -; mRNA.
DR   RefSeq; NP_445785.1; NM_053333.1.
DR   RefSeq; XP_006248345.1; XM_006248283.3.
DR   AlphaFoldDB; Q99P85; -.
DR   SMR; Q99P85; -.
DR   STRING; 10116.ENSRNOP00000002676; -.
DR   PaxDb; Q99P85; -.
DR   GeneID; 81712; -.
DR   KEGG; rno:81712; -.
DR   UCSC; RGD:68349; rat.
DR   CTD; 57262; -.
DR   RGD; 68349; Retnla.
DR   VEuPathDB; HostDB:ENSRNOG00000001955; -.
DR   eggNOG; ENOG502RTZZ; Eukaryota.
DR   HOGENOM; CLU_150117_0_0_1; -.
DR   InParanoid; Q99P85; -.
DR   OMA; CHCLCPV; -.
DR   OrthoDB; 1541877at2759; -.
DR   PhylomeDB; Q99P85; -.
DR   TreeFam; TF337024; -.
DR   PRO; PR:Q99P85; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000001955; Expressed in lung and 6 other tissues.
DR   Genevisible; Q99P85; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd16333; RELM; 1.
DR   Gene3D; 2.60.40.4230; -; 1.
DR   InterPro; IPR009714; RELM.
DR   InterPro; IPR036262; Resistin-like_sf.
DR   PANTHER; PTHR21101; PTHR21101; 1.
DR   Pfam; PF06954; Resistin; 1.
DR   SUPFAM; SSF111423; SSF111423; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..111
FT                   /note="Resistin-like alpha"
FT                   /id="PRO_0000030344"
FT   DISULFID        55..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..95
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..97
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   111 AA;  12076 MW;  001AF5C1B14CC3D7 CRC64;
     MKTATCSLLI CVFLLQLMVP VNTDGTLDII GKKKVKELLA HQDNYPSAVR KTLSCTNVKS
     MSKWASCPAG MTATGCSCGF ACGSWEIQNE NICNCLCLIV DWAYARCCQL S