RETNB_HUMAN
ID RETNB_HUMAN Reviewed; 111 AA.
AC Q9BQ08; Q14D27;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Resistin-like beta;
DE AltName: Full=Colon and small intestine-specific cysteine-rich protein;
DE AltName: Full=Colon carcinoma-related gene protein;
DE AltName: Full=Cysteine-rich secreted protein A12-alpha-like 1;
DE AltName: Full=Cysteine-rich secreted protein FIZZ2;
DE AltName: Full=RELMbeta;
DE Flags: Precursor;
GN Name=RETNLB; Synonyms=CCRG, FIZZ2, HXCP2, RETNL2; ORFNames=UNQ408/PRO770;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11090083;
RA Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H.,
RA Koeffler H.P.;
RT "Representational difference analysis using myeloid cells from C/EBP
RT epsilon deletional mice.";
RL Blood 96:3953-3957(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11209052; DOI=10.1073/pnas.98.2.502;
RA Steppan C.M., Brown E.J., Wright C.M., Bhat S., Banerjee R.R., Dai C.Y.,
RA Enders G.H., Silberg D.G., Wen X., Wu G.D., Lazar M.A.;
RT "A family of tissue-specific resistin-like molecules.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:502-506(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rajala M.W., Scherer P.E.;
RT "Identification of a novel cysteine-rich secreted A12-alpha related
RT protein.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RX PubMed=12224133;
RA De Young M.P., Damania H., Scheurle D., Zylberberg C., Narayanan R.;
RT "Bioinformatics based discovery of a novel factor with apparent specificity
RT to colon cancer.";
RL In Vivo 16:239-248(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable hormone.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed only in the gastrointestinal tract,
CC particularly the colon.
CC -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
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DR EMBL; AF352731; AAK18622.1; -; Genomic_DNA.
DR EMBL; AF323084; AAG59827.1; -; mRNA.
DR EMBL; AF290873; AAK83105.1; -; mRNA.
DR EMBL; AF323921; AAL96378.1; -; mRNA.
DR EMBL; AY358655; AAQ89018.1; -; mRNA.
DR EMBL; BC069318; AAH69318.1; -; mRNA.
DR EMBL; BC113502; AAI13503.1; -; mRNA.
DR EMBL; BC113528; AAI13529.1; -; mRNA.
DR CCDS; CCDS2953.1; -.
DR RefSeq; NP_115968.1; NM_032579.2.
DR AlphaFoldDB; Q9BQ08; -.
DR SMR; Q9BQ08; -.
DR BioGRID; 124186; 22.
DR STRING; 9606.ENSP00000295755; -.
DR TCDB; 9.B.329.1.2; the resistin-like molecule (relm) family.
DR BioMuta; RETNLB; -.
DR DMDM; 18202730; -.
DR MassIVE; Q9BQ08; -.
DR PaxDb; Q9BQ08; -.
DR PeptideAtlas; Q9BQ08; -.
DR PRIDE; Q9BQ08; -.
DR ProteomicsDB; 78607; -.
DR Antibodypedia; 16152; 362 antibodies from 35 providers.
DR DNASU; 84666; -.
DR Ensembl; ENST00000295755.7; ENSP00000295755.6; ENSG00000163515.7.
DR GeneID; 84666; -.
DR KEGG; hsa:84666; -.
DR MANE-Select; ENST00000295755.7; ENSP00000295755.6; NM_032579.3; NP_115968.1.
DR UCSC; uc003dxh.3; human.
DR CTD; 84666; -.
DR DisGeNET; 84666; -.
DR GeneCards; RETNLB; -.
DR HGNC; HGNC:20388; RETNLB.
DR HPA; ENSG00000163515; Tissue enriched (intestine).
DR MIM; 605645; gene.
DR neXtProt; NX_Q9BQ08; -.
DR OpenTargets; ENSG00000163515; -.
DR PharmGKB; PA134906814; -.
DR VEuPathDB; HostDB:ENSG00000163515; -.
DR eggNOG; ENOG502RTZZ; Eukaryota.
DR GeneTree; ENSGT00390000016177; -.
DR HOGENOM; CLU_150117_0_0_1; -.
DR InParanoid; Q9BQ08; -.
DR OMA; CQCSVVD; -.
DR OrthoDB; 1541877at2759; -.
DR PhylomeDB; Q9BQ08; -.
DR TreeFam; TF337024; -.
DR PathwayCommons; Q9BQ08; -.
DR BioGRID-ORCS; 84666; 15 hits in 1062 CRISPR screens.
DR ChiTaRS; RETNLB; human.
DR GeneWiki; RETNLB; -.
DR GenomeRNAi; 84666; -.
DR Pharos; Q9BQ08; Tbio.
DR PRO; PR:Q9BQ08; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BQ08; protein.
DR Bgee; ENSG00000163515; Expressed in ileal mucosa and 59 other tissues.
DR Genevisible; Q9BQ08; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0050673; P:epithelial cell proliferation; IEP:UniProtKB.
DR CDD; cd16333; RELM; 1.
DR Gene3D; 2.60.40.4230; -; 1.
DR InterPro; IPR009714; RELM.
DR InterPro; IPR036262; Resistin-like_sf.
DR PANTHER; PTHR21101; PTHR21101; 1.
DR Pfam; PF06954; Resistin; 1.
DR SUPFAM; SSF111423; SSF111423; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..111
FT /note="Resistin-like beta"
FT /id="PRO_0000030345"
FT DISULFID 25
FT /note="Interchain"
FT /evidence="ECO:0000305"
FT DISULFID 55..108
FT /evidence="ECO:0000250"
FT DISULFID 67..107
FT /evidence="ECO:0000250"
FT DISULFID 76..93
FT /evidence="ECO:0000250"
FT DISULFID 78..95
FT /evidence="ECO:0000250"
FT DISULFID 82..97
FT /evidence="ECO:0000250"
FT VARIANT 20
FT /note="P -> L (in dbSNP:rs11708527)"
FT /id="VAR_051791"
SQ SEQUENCE 111 AA; 11730 MW; BD64233AF302B4C0 CRC64;
MGPSSCLLLI LIPLLQLINP GSTQCSLDSV MDKKIKDVLN SLEYSPSPIS KKLSCASVKS
QGRPSSCPAG MAVTGCACGY GCGSWDVQLE TTCHCQCSVV DWTTARCCHL T
