RETNG_MOUSE
ID RETNG_MOUSE Reviewed; 117 AA.
AC Q8K426; Q7TM98;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Resistin-like gamma {ECO:0000312|MGI:MGI:2667763};
DE AltName: Full=Resistin-like molecule gamma {ECO:0000303|PubMed:12782128};
DE Short=RELMgamma {ECO:0000303|PubMed:12782128};
DE AltName: Full=Ten-cysteine protein 1 {ECO:0000303|PubMed:15064728};
DE Short=XCP1 {ECO:0000303|PubMed:15064728};
DE Flags: Precursor;
GN Name=Retnlg {ECO:0000312|MGI:MGI:2667763};
GN Synonyms=Xcp1 {ECO:0000303|PubMed:15064728};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:CAD56117.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=CD-1 {ECO:0000312|EMBL:CAD56117.1};
RX PubMed=12782128; DOI=10.1016/s0888-7543(03)00070-3;
RA Gerstmayer B., Kuesters D., Gebel S., Mueller T., Van Miert E., Hofmann K.,
RA Bosio A.;
RT "Identification of RELMgamma, a novel resistin-like molecule with a
RT distinct expression pattern.";
RL Genomics 81:588-595(2003).
RN [2] {ECO:0000312|EMBL:CAD59912.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:CAD59912.1};
RC TISSUE=Bone marrow {ECO:0000312|EMBL:CAD59912.1};
RX PubMed=14733912; DOI=10.1016/j.bbrc.2003.12.100;
RA Schinke T., Haberland M., Jamshidi A., Nollau P., Rueger J.M., Amling M.;
RT "Cloning and functional characterization of resistin-like molecule gamma.";
RL Biochem. Biophys. Res. Commun. 314:356-362(2004).
RN [3] {ECO:0000312|EMBL:AAM46859.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15064728; DOI=10.1038/sj.onc.1207126;
RA Chumakov A.M., Kubota T., Walter S., Koeffler H.P.;
RT "Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent
RT members of FIZZ/Resistin gene family.";
RL Oncogene 23:3414-3425(2004).
RN [4] {ECO:0000312|EMBL:BAC78641.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RX PubMed=15834545; DOI=10.1007/s00125-005-1735-1;
RA Shojima N., Ogihara T., Inukai K., Fujishiro M., Sakoda H., Kushiyama A.,
RA Katagiri H., Anai M., Ono H., Fukushima Y., Horike N., Viana A.Y.,
RA Uchijima Y., Kurihara H., Asano T.;
RT "Serum concentrations of resistin-like molecules beta and gamma are
RT elevated in high-fat-fed and obese db/db mice, with increased production in
RT the intestinal tract and bone marrow.";
RL Diabetologia 48:984-992(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [6] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [7] {ECO:0000312|EMBL:EDK98100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000312|EMBL:AAI17107.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAI17107.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable hormone (Probable). Promotes chemotaxis in myeloid
CC cells (PubMed:15064728). {ECO:0000269|PubMed:15064728, ECO:0000305}.
CC -!- SUBUNIT: Homodimer. Heterodimer with RETNLB.
CC {ECO:0000269|PubMed:15834545}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14733912,
CC ECO:0000269|PubMed:15064728, ECO:0000269|PubMed:15834545}.
CC -!- TISSUE SPECIFICITY: Expressed in colon, lung, spleen, pancreas, ileum
CC and bone marrow (at protein level) (PubMed:15834545). In colon, found
CC throughout the crypt and surface epithelium, including goblet cells (at
CC protein level) (PubMed:15834545). Highest expression is observed in
CC bone marrow, spleen and lung, with lower levels in other tissues
CC (PubMed:12782128, PubMed:14733912, PubMed:15064728, PubMed:15834545).
CC Detected at low levels in granulocytes, but not found in monocytes or
CC lymphocytes (PubMed:14733912). Has very weak expression in white
CC adipose tissue (PubMed:12782128). {ECO:0000269|PubMed:12782128,
CC ECO:0000269|PubMed:14733912, ECO:0000269|PubMed:15064728,
CC ECO:0000269|PubMed:15834545}.
CC -!- DEVELOPMENTAL STAGE: In liver, strongly expressed at 18 dpc and at
CC birth, and then rapidly declines. In pancreas, strongly expressed at
CC birth with decreasing expression after 4 days of age. Also shows strong
CC expression in neonatal gut, lung and heart.
CC {ECO:0000269|PubMed:15064728}.
CC -!- INDUCTION: Up-regulated in colon and bone marrow in response to a high-
CC fat diet. Also up-regulated in obese mice mutant for the leptin
CC receptor LEPR (db/db genotype). {ECO:0000269|PubMed:15834545}.
CC -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC78641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD56117.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ514933; CAD56117.1; ALT_INIT; mRNA.
DR EMBL; AJ536019; CAD59912.1; -; mRNA.
DR EMBL; AF510097; AAM46859.1; -; Genomic_DNA.
DR EMBL; AB086819; BAC78641.1; ALT_INIT; mRNA.
DR EMBL; AK158401; BAE34489.1; -; mRNA.
DR EMBL; AC154529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466521; EDK98100.1; -; Genomic_DNA.
DR EMBL; CH466521; EDK98101.1; -; Genomic_DNA.
DR EMBL; BC117106; AAI17107.1; ALT_INIT; mRNA.
DR CCDS; CCDS49865.1; -.
DR RefSeq; NP_853627.2; NM_181596.4.
DR AlphaFoldDB; Q8K426; -.
DR SMR; Q8K426; -.
DR STRING; 10090.ENSMUSP00000070238; -.
DR TCDB; 9.B.329.1.3; the resistin-like molecule (relm) family.
DR MaxQB; Q8K426; -.
DR PaxDb; Q8K426; -.
DR PRIDE; Q8K426; -.
DR ProteomicsDB; 255229; -.
DR Ensembl; ENSMUST00000065666; ENSMUSP00000070238; ENSMUSG00000022651.
DR GeneID; 245195; -.
DR KEGG; mmu:245195; -.
DR UCSC; uc007zjw.2; mouse.
DR CTD; 245195; -.
DR MGI; MGI:2667763; Retnlg.
DR VEuPathDB; HostDB:ENSMUSG00000022651; -.
DR eggNOG; ENOG502RTZZ; Eukaryota.
DR GeneTree; ENSGT00390000016177; -.
DR HOGENOM; CLU_150117_0_0_1; -.
DR InParanoid; Q8K426; -.
DR OMA; WATARCC; -.
DR OrthoDB; 1541877at2759; -.
DR PhylomeDB; Q8K426; -.
DR TreeFam; TF337024; -.
DR BioGRID-ORCS; 245195; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8K426; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8K426; protein.
DR Bgee; ENSMUSG00000022651; Expressed in granulocyte and 39 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0002408; P:myeloid dendritic cell chemotaxis; IPI:MGI.
DR CDD; cd16333; RELM; 1.
DR Gene3D; 2.60.40.4230; -; 1.
DR InterPro; IPR009714; RELM.
DR InterPro; IPR036262; Resistin-like_sf.
DR PANTHER; PTHR21101; PTHR21101; 1.
DR Pfam; PF06954; Resistin; 1.
DR SUPFAM; SSF111423; SSF111423; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..117
FT /note="Resistin-like gamma"
FT /id="PRO_5009715783"
FT DISULFID 61..114
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 73..113
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 82..99
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 84..101
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 88..103
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
SQ SEQUENCE 117 AA; 12535 MW; 19082CBB26E4A0BA CRC64;
MLTFNKMKTT TCSLLICISL LQLMVPVNTE GTLESIVEKK VKELLANRDD CPSTVTKTFS
CTSITASGRL ASCPSGMTVT GCACGYGCGS WDIRDGNTCH CQCSTMDWAT ARCCQLA
