RETNG_RAT
ID RETNG_RAT Reviewed; 111 AA.
AC G3V686; Q7TN86;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Resistin-like gamma {ECO:0000312|RGD:727934};
DE AltName: Full=Resistin-like molecule gamma {ECO:0000303|PubMed:12782128};
DE Short=RELMgamma {ECO:0000303|PubMed:12782128};
DE Flags: Precursor;
GN Name=Retnlg {ECO:0000312|RGD:727934};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|Proteomes:UP000002494};
RN [1] {ECO:0000312|EMBL:CAD56116.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:CAD56116.1};
RX PubMed=12782128; DOI=10.1016/s0888-7543(03)00070-3;
RA Gerstmayer B., Kuesters D., Gebel S., Mueller T., Van Miert E., Hofmann K.,
RA Bosio A.;
RT "Identification of RELMgamma, a novel resistin-like molecule with a
RT distinct expression pattern.";
RL Genomics 81:588-595(2003).
RN [2] {ECO:0000312|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000312|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3] {ECO:0000312|EMBL:EDM11108.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000312|EMBL:EDM11108.1};
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable hormone (Probable). Promotes chemotaxis in myeloid
CC cells (By similarity). {ECO:0000250|UniProtKB:Q8K426, ECO:0000305}.
CC -!- SUBUNIT: Homodimer. Heterodimer with RETNLB.
CC {ECO:0000250|UniProtKB:Q8K426}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8K426}.
CC -!- TISSUE SPECIFICITY: Highly expressed in bone marrow, spleen and white
CC blood cells. Also detected at low levels in thymus, lung, trachea,
CC white adipose tissue, nasal respiratory epithelium, colon, small
CC intestine, kidney, liver, and heart. {ECO:0000269|PubMed:12782128}.
CC -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
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DR EMBL; AJ514932; CAD56116.1; -; mRNA.
DR EMBL; AC130920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473967; EDM11108.1; -; Genomic_DNA.
DR RefSeq; NP_853656.1; NM_181625.1.
DR RefSeq; XP_006248344.1; XM_006248282.3.
DR AlphaFoldDB; G3V686; -.
DR SMR; G3V686; -.
DR STRING; 10116.ENSRNOP00000002673; -.
DR PaxDb; G3V686; -.
DR GeneID; 288135; -.
DR KEGG; rno:288135; -.
DR CTD; 245195; -.
DR RGD; 727934; Retnlg.
DR VEuPathDB; HostDB:ENSRNOG00000001943; -.
DR eggNOG; ENOG502RTZZ; Eukaryota.
DR HOGENOM; CLU_150117_0_0_1; -.
DR InParanoid; G3V686; -.
DR OMA; WATARCC; -.
DR OrthoDB; 1541877at2759; -.
DR PhylomeDB; G3V686; -.
DR TreeFam; TF337024; -.
DR PRO; PR:G3V686; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Proteomes; UP000234681; Chromosome 11.
DR Bgee; ENSRNOG00000001943; Expressed in spleen and 17 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; NAS:RGD.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0002408; P:myeloid dendritic cell chemotaxis; IEA:Ensembl.
DR CDD; cd16333; RELM; 1.
DR Gene3D; 2.60.40.4230; -; 1.
DR InterPro; IPR009714; RELM.
DR InterPro; IPR036262; Resistin-like_sf.
DR PANTHER; PTHR21101; PTHR21101; 1.
DR Pfam; PF06954; Resistin; 1.
DR SUPFAM; SSF111423; SSF111423; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..111
FT /note="Resistin-like gamma"
FT /id="PRO_5009691761"
FT DISULFID 55..108
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 67..107
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 76..93
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 78..95
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT DISULFID 82..97
FT /evidence="ECO:0000250|UniProtKB:Q99P87"
FT CONFLICT 5
FT /note="I -> T (in Ref. 1; CAD56116)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="N -> S (in Ref. 1; CAD56116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 11822 MW; 6D57DED7C75AE2EE CRC64;
MKTAICSLLI CIFLLQLMVP VNTDGTLESI VEQKVKELLA HRDNCPSTVT KTLSCTSVKA
TGRLASCPPG MAVTGCACGY ACGSWDIRDG TTCHCQCAVM DWATARCCQL S
