ID   RETN_BOVIN              Reviewed;         109 AA.
AC   Q762I5; A6QLM9; Q6IVW9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Resistin;
DE   Flags: Precursor;
GN   Name=RETN; Synonyms=RSTN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Komatsu T., Itoh F., Hodate K., Hazegawa S., Obara Y., Kushibiki S.;
RT   "Gene expression of resistin and TNF-alpha in adipose tissue of Japanese
RT   Black steers and Holstein steers.";
RL   Anim. Sci. J. 76:567-573(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Korean;
RA   Chung E.R., Shin S.C., Kim W.T.;
RT   "Cloning and sequence of ADSF/resistin gene in Korean cattle.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Korean;
RX   AGRICOLA=IND43794247;
RA   Kang H.K., Park J.A., Seo K.S., Kim S.H., Choi Y.J., Moon Y.S.;
RT   "Characteristics of structure and expression pattern of ADSF/resistin gene
RT   in Korean native cattle.";
RL   Asian-Australas. J. Anim. Sci. 19:329-334(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hormone that seems to suppress insulin ability to stimulate
CC       glucose uptake into adipose cells. Potentially links obesity to
CC       diabetes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
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DR   EMBL; AB117718; BAC82041.1; -; mRNA.
DR   EMBL; DQ125240; AAZ32259.1; -; Genomic_DNA.
DR   EMBL; AY618903; AAT40142.2; -; Genomic_DNA.
DR   EMBL; BC148022; AAI48023.1; -; mRNA.
DR   RefSeq; NP_899206.1; NM_183362.1.
DR   AlphaFoldDB; Q762I5; -.
DR   SMR; Q762I5; -.
DR   STRING; 9913.ENSBTAP00000006189; -.
DR   PaxDb; Q762I5; -.
DR   PeptideAtlas; Q762I5; -.
DR   PRIDE; Q762I5; -.
DR   Ensembl; ENSBTAT00000006189; ENSBTAP00000006189; ENSBTAG00000004716.
DR   GeneID; 369020; -.
DR   KEGG; bta:369020; -.
DR   CTD; 56729; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004716; -.
DR   VGNC; VGNC:33877; RETN.
DR   eggNOG; ENOG502S9XN; Eukaryota.
DR   GeneTree; ENSGT00390000016177; -.
DR   HOGENOM; CLU_150117_0_0_1; -.
DR   InParanoid; Q762I5; -.
DR   OMA; CACGSAC; -.
DR   OrthoDB; 1541877at2759; -.
DR   TreeFam; TF337024; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000004716; Expressed in monocyte and 74 other tissues.
DR   ExpressionAtlas; Q762I5; baseline.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; IMP:AgBase.
DR   CDD; cd16333; RELM; 1.
DR   Gene3D; 2.60.40.4230; -; 1.
DR   InterPro; IPR009714; RELM.
DR   InterPro; IPR036262; Resistin-like_sf.
DR   PANTHER; PTHR21101; PTHR21101; 1.
DR   Pfam; PF06954; Resistin; 1.
DR   SUPFAM; SSF111423; SSF111423; 1.
PE   3: Inferred from homology;
KW   Diabetes mellitus; Disulfide bond; Hormone; Obesity; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..109
FT                   /note="Resistin"
FT                   /id="PRO_0000236238"
FT   DISULFID        22
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..89
FT                   /evidence="ECO:0000250"
FT   DISULFID        74..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..93
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  11469 MW;  AE3A0A9825C97D4D CRC64;
     MKALSFLFIP VLGLLVCGQS LCPIDKAISE KIQEVTTSLV PGAVRIIGLD CRSVTSRGSL
     VTCPSGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG ARCCRLHIQ