RETN_MOUSE
ID RETN_MOUSE Reviewed; 114 AA.
AC Q99P87;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Resistin;
DE AltName: Full=Adipose tissue-specific secretory factor;
DE Short=ADSF;
DE AltName: Full=Adipose-specific cysteine-rich secreted protein A12-alpha;
DE AltName: Full=Cysteine-rich secreted protein FIZZ3;
DE Flags: Precursor;
GN Name=Retn; Synonyms=Fizz3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11201732; DOI=10.1038/35053000;
RA Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M.,
RA Patel H.R., Ahima R.S., Lazar M.A.;
RT "The hormone resistin links obesity to diabetes.";
RL Nature 409:307-312(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rajala M.W., Scherer P.E.;
RT "Identification of a novel adipose-specific cysteine-rich secreted
RT protein.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBUNIT.
RX PubMed=11358969; DOI=10.1074/jbc.m103109200;
RA Banerjee R.R., Lazar M.A.;
RT "Dimerization of resistin and resistin-like molecules is determined by a
RT single cysteine.";
RL J. Biol. Chem. 276:25970-25973(2001).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-114, AND DISULFIDE BONDS.
RX PubMed=15155948; DOI=10.1126/science.1093466;
RA Patel S.D., Rajala M.W., Rossetti L., Scherer P.E., Shapiro L.;
RT "Disulfide-dependent multimeric assembly of resistin family hormones.";
RL Science 304:1154-1158(2004).
CC -!- FUNCTION: Hormone that seems to suppress insulin ability to stimulate
CC glucose uptake into adipose cells. Potentially links obesity to
CC diabetes. {ECO:0000269|PubMed:11201732}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:11358969,
CC ECO:0000269|PubMed:15155948}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11201732}.
CC -!- TISSUE SPECIFICITY: Expressed in white but not brown adipose tissue in
CC a variety of organs. {ECO:0000269|PubMed:11201732}.
CC -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
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DR EMBL; AF323080; AAG59823.1; -; mRNA.
DR EMBL; AF290870; AAK83102.1; -; mRNA.
DR EMBL; BC051196; AAH51196.1; -; mRNA.
DR CCDS; CCDS22068.1; -.
DR RefSeq; NP_001191888.1; NM_001204959.1.
DR RefSeq; NP_075360.1; NM_022984.4.
DR PDB; 1RFX; X-ray; 2.00 A; A/B/C=21-114.
DR PDB; 1RGX; X-ray; 1.79 A; A/B/C=1-114.
DR PDBsum; 1RFX; -.
DR PDBsum; 1RGX; -.
DR AlphaFoldDB; Q99P87; -.
DR SMR; Q99P87; -.
DR CORUM; Q99P87; -.
DR STRING; 10090.ENSMUSP00000133024; -.
DR MaxQB; Q99P87; -.
DR PaxDb; Q99P87; -.
DR PeptideAtlas; Q99P87; -.
DR PRIDE; Q99P87; -.
DR ProteomicsDB; 253223; -.
DR Antibodypedia; 12160; 877 antibodies from 38 providers.
DR Ensembl; ENSMUST00000012849; ENSMUSP00000012849; ENSMUSG00000012705.
DR Ensembl; ENSMUST00000169234; ENSMUSP00000133024; ENSMUSG00000012705.
DR GeneID; 57264; -.
DR KEGG; mmu:57264; -.
DR UCSC; uc009ksg.2; mouse.
DR CTD; 56729; -.
DR MGI; MGI:1888506; Retn.
DR VEuPathDB; HostDB:ENSMUSG00000012705; -.
DR eggNOG; ENOG502S9XN; Eukaryota.
DR GeneTree; ENSGT00390000016177; -.
DR HOGENOM; CLU_150117_0_0_1; -.
DR InParanoid; Q99P87; -.
DR OMA; CACGSAC; -.
DR OrthoDB; 1541877at2759; -.
DR PhylomeDB; Q99P87; -.
DR TreeFam; TF337024; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 57264; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Retn; mouse.
DR EvolutionaryTrace; Q99P87; -.
DR PRO; PR:Q99P87; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q99P87; protein.
DR Bgee; ENSMUSG00000012705; Expressed in white adipose tissue and 94 other tissues.
DR ExpressionAtlas; Q99P87; baseline and differential.
DR Genevisible; Q99P87; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0045444; P:fat cell differentiation; ISO:MGI.
DR GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
DR GO; GO:0010714; P:positive regulation of collagen metabolic process; ISO:MGI.
DR GO; GO:2000872; P:positive regulation of progesterone secretion; ISO:MGI.
DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISO:MGI.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; ISO:MGI.
DR GO; GO:0032868; P:response to insulin; ISO:MGI.
DR CDD; cd16333; RELM; 1.
DR Gene3D; 2.60.40.4230; -; 1.
DR InterPro; IPR009714; RELM.
DR InterPro; IPR036262; Resistin-like_sf.
DR PANTHER; PTHR21101; PTHR21101; 1.
DR Pfam; PF06954; Resistin; 1.
DR SUPFAM; SSF111423; SSF111423; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Diabetes mellitus; Direct protein sequencing; Disulfide bond;
KW Hormone; Obesity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT CHAIN 21..114
FT /note="Resistin"
FT /id="PRO_0000030342"
FT DISULFID 26
FT /note="Interchain"
FT /evidence="ECO:0000305|PubMed:15155948"
FT DISULFID 55..108
FT /evidence="ECO:0000269|PubMed:15155948"
FT DISULFID 67..107
FT /evidence="ECO:0000269|PubMed:15155948"
FT DISULFID 76..93
FT /evidence="ECO:0000269|PubMed:15155948"
FT DISULFID 78..95
FT /evidence="ECO:0000269|PubMed:15155948"
FT DISULFID 82..97
FT /evidence="ECO:0000269|PubMed:15155948"
FT HELIX 28..48
FT /evidence="ECO:0007829|PDB:1RGX"
FT STRAND 51..66
FT /evidence="ECO:0007829|PDB:1RGX"
FT STRAND 72..79
FT /evidence="ECO:0007829|PDB:1RGX"
FT STRAND 85..88
FT /evidence="ECO:0007829|PDB:1RGX"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:1RGX"
FT STRAND 92..95
FT /evidence="ECO:0007829|PDB:1RGX"
FT STRAND 101..112
FT /evidence="ECO:0007829|PDB:1RGX"
SQ SEQUENCE 114 AA; 12492 MW; D44930E51D3F22C8 CRC64;
MKNLSFPLLF LFFLVPELLG SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS
RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS
