RETR3_HUMAN
ID RETR3_HUMAN Reviewed; 466 AA.
AC Q86VR2; B3KR75;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Reticulophagy regulator 3;
GN Name=RETREG3 {ECO:0000312|HGNC:HGNC:27258}; Synonyms=FAM134C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-283;
RP SER-285; THR-307; THR-310; SER-313; SER-320; SER-360 AND THR-440, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-260; THR-307;
RP SER-313; SER-320 AND THR-440, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT THR-10; SER-258 AND SER-260, CLEAVAGE OF INITIATOR METHIONINE
RP [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
RP SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-258; SER-260 AND
RP SER-320, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [12]
RP FUNCTION.
RX PubMed=23939472; DOI=10.1016/j.gene.2013.08.006;
RA Wang J.L., Tong C.W., Chang W.T., Huang A.M.;
RT "Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and
RT differentially regulate neurite outgrowth in neuroblastoma cells and
RT hippocampal neurons.";
RL Gene 529:7-15(2013).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10 AND SER-320, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-307; THR-310; SER-313 AND
RP SER-320, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [15]
RP INTERACTION WITH MAP1LC3A; MAP1LC3B; GABARAP AND GABARAPL1, AND DOMAIN.
RX PubMed=26040720; DOI=10.1038/nature14498;
RA Khaminets A., Heinrich T., Mari M., Grumati P., Huebner A.K., Akutsu M.,
RA Liebmann L., Stolz A., Nietzsche S., Koch N., Mauthe M., Katona I.,
RA Qualmann B., Weis J., Reggiori F., Kurth I., Huebner C.A., Dikic I.;
RT "Regulation of endoplasmic reticulum turnover by selective autophagy.";
RL Nature 522:354-358(2015).
CC -!- FUNCTION: Mediates NRF1-enhanced neurite outgrowth.
CC {ECO:0000269|PubMed:23939472}.
CC -!- SUBUNIT: Interacts with ATG8 family modifier proteins MAP1LC3A,
CC MAP1LC3B, GABARAP, and GABARAPL1. {ECO:0000269|PubMed:26040720}.
CC -!- INTERACTION:
CC Q86VR2; O95870: ABHD16A; NbExp=7; IntAct=EBI-10192441, EBI-348517;
CC Q86VR2; Q9ULC5: ACSL5; NbExp=5; IntAct=EBI-10192441, EBI-2876927;
CC Q86VR2; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-10192441, EBI-1754287;
CC Q86VR2; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-10192441, EBI-11522760;
CC Q86VR2; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-10192441, EBI-12109402;
CC Q86VR2; Q15041: ARL6IP1; NbExp=7; IntAct=EBI-10192441, EBI-714543;
CC Q86VR2; O15145: ARPC3; NbExp=5; IntAct=EBI-10192441, EBI-351829;
CC Q86VR2; P27449: ATP6V0C; NbExp=3; IntAct=EBI-10192441, EBI-721179;
CC Q86VR2; O15155: BET1; NbExp=3; IntAct=EBI-10192441, EBI-749204;
CC Q86VR2; Q12981: BNIP1; NbExp=3; IntAct=EBI-10192441, EBI-4402847;
CC Q86VR2; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-10192441, EBI-12003442;
CC Q86VR2; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-10192441, EBI-9083477;
CC Q86VR2; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-10192441, EBI-10271156;
CC Q86VR2; O14735: CDIPT; NbExp=3; IntAct=EBI-10192441, EBI-358858;
CC Q86VR2; Q92903: CDS1; NbExp=3; IntAct=EBI-10192441, EBI-13295305;
CC Q86VR2; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-10192441, EBI-7247651;
CC Q86VR2; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-10192441, EBI-11522780;
CC Q86VR2; Q96FZ5: CMTM7; NbExp=5; IntAct=EBI-10192441, EBI-2807956;
CC Q86VR2; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-10192441, EBI-10267100;
CC Q86VR2; O43169: CYB5B; NbExp=3; IntAct=EBI-10192441, EBI-1058710;
CC Q86VR2; P78329: CYP4F2; NbExp=3; IntAct=EBI-10192441, EBI-1752413;
CC Q86VR2; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-10192441, EBI-398977;
CC Q86VR2; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-10192441, EBI-3923585;
CC Q86VR2; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-10192441, EBI-711490;
CC Q86VR2; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-10192441, EBI-12142299;
CC Q86VR2; Q96LL3: FIMP; NbExp=3; IntAct=EBI-10192441, EBI-12887376;
CC Q86VR2; Q14318: FKBP8; NbExp=3; IntAct=EBI-10192441, EBI-724839;
CC Q86VR2; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-10192441, EBI-714482;
CC Q86VR2; Q9H0R8: GABARAPL1; NbExp=8; IntAct=EBI-10192441, EBI-746969;
CC Q86VR2; P60520: GABARAPL2; NbExp=3; IntAct=EBI-10192441, EBI-720116;
CC Q86VR2; Q96F15: GIMAP5; NbExp=5; IntAct=EBI-10192441, EBI-6166686;
CC Q86VR2; O14653: GOSR2; NbExp=3; IntAct=EBI-10192441, EBI-4401517;
CC Q86VR2; P30519: HMOX2; NbExp=3; IntAct=EBI-10192441, EBI-712096;
CC Q86VR2; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-10192441, EBI-12937691;
CC Q86VR2; Q01628: IFITM3; NbExp=3; IntAct=EBI-10192441, EBI-7932862;
CC Q86VR2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10192441, EBI-10266796;
CC Q86VR2; Q68G75: LEMD1; NbExp=3; IntAct=EBI-10192441, EBI-12268900;
CC Q86VR2; Q9UBY5: LPAR3; NbExp=5; IntAct=EBI-10192441, EBI-12033434;
CC Q86VR2; Q7L5N7: LPCAT2; NbExp=3; IntAct=EBI-10192441, EBI-4280011;
CC Q86VR2; O75427: LRCH4; NbExp=3; IntAct=EBI-10192441, EBI-718707;
CC Q86VR2; Q969L2: MAL2; NbExp=3; IntAct=EBI-10192441, EBI-944295;
CC Q86VR2; Q13021: MALL; NbExp=3; IntAct=EBI-10192441, EBI-750078;
CC Q86VR2; Q9H492: MAP1LC3A; NbExp=9; IntAct=EBI-10192441, EBI-720768;
CC Q86VR2; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-10192441, EBI-348259;
CC Q86VR2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10192441, EBI-11956541;
CC Q86VR2; Q70IA6: MOB2; NbExp=3; IntAct=EBI-10192441, EBI-2558739;
CC Q86VR2; O75425: MOSPD3; NbExp=3; IntAct=EBI-10192441, EBI-12179105;
CC Q86VR2; Q8IXM6: NRM; NbExp=3; IntAct=EBI-10192441, EBI-10262547;
CC Q86VR2; Q96CV9: OPTN; NbExp=3; IntAct=EBI-10192441, EBI-748974;
CC Q86VR2; Q53FV1: ORMDL2; NbExp=3; IntAct=EBI-10192441, EBI-11075081;
CC Q86VR2; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-10192441, EBI-721750;
CC Q86VR2; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-10192441, EBI-6916492;
CC Q86VR2; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-10192441, EBI-12257782;
CC Q86VR2; Q04941: PLP2; NbExp=3; IntAct=EBI-10192441, EBI-608347;
CC Q86VR2; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-10192441, EBI-11721828;
CC Q86VR2; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-10192441, EBI-8652812;
CC Q86VR2; O60831: PRAF2; NbExp=3; IntAct=EBI-10192441, EBI-2506064;
CC Q86VR2; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-10192441, EBI-712367;
CC Q86VR2; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-10192441, EBI-14065960;
CC Q86VR2; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-10192441, EBI-8636004;
CC Q86VR2; O00767: SCD; NbExp=3; IntAct=EBI-10192441, EBI-2684237;
CC Q86VR2; Q96IW7: SEC22A; NbExp=5; IntAct=EBI-10192441, EBI-8652744;
CC Q86VR2; Q9HC62: SENP2; NbExp=3; IntAct=EBI-10192441, EBI-714881;
CC Q86VR2; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-10192441, EBI-749270;
CC Q86VR2; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-10192441, EBI-2854842;
CC Q86VR2; A0A1P0AYU5: SFXN3; NbExp=5; IntAct=EBI-10192441, EBI-14193895;
CC Q86VR2; Q99726: SLC30A3; NbExp=3; IntAct=EBI-10192441, EBI-10294651;
CC Q86VR2; Q13433-2: SLC39A6; NbExp=3; IntAct=EBI-10192441, EBI-12956703;
CC Q86VR2; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-10192441, EBI-8640191;
CC Q86VR2; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-10192441, EBI-12188413;
CC Q86VR2; Q9ULZ2: STAP1; NbExp=8; IntAct=EBI-10192441, EBI-6083058;
CC Q86VR2; Q13190: STX5; NbExp=3; IntAct=EBI-10192441, EBI-714206;
CC Q86VR2; O15400: STX7; NbExp=3; IntAct=EBI-10192441, EBI-3221827;
CC Q86VR2; Q9UNK0: STX8; NbExp=5; IntAct=EBI-10192441, EBI-727240;
CC Q86VR2; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-10192441, EBI-12187159;
CC Q86VR2; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-10192441, EBI-702328;
CC Q86VR2; Q15560: TCEA2; NbExp=3; IntAct=EBI-10192441, EBI-710310;
CC Q86VR2; Q9NZ01: TECR; NbExp=3; IntAct=EBI-10192441, EBI-2877718;
CC Q86VR2; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-10192441, EBI-8644968;
CC Q86VR2; P17152: TMEM11; NbExp=3; IntAct=EBI-10192441, EBI-723946;
CC Q86VR2; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-10192441, EBI-10171534;
CC Q86VR2; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-10192441, EBI-10694905;
CC Q86VR2; Q96HP8: TMEM176A; NbExp=3; IntAct=EBI-10192441, EBI-2800645;
CC Q86VR2; Q96B42-2: TMEM18; NbExp=3; IntAct=EBI-10192441, EBI-17196383;
CC Q86VR2; Q969S6: TMEM203; NbExp=3; IntAct=EBI-10192441, EBI-12274070;
CC Q86VR2; A2RU14: TMEM218; NbExp=3; IntAct=EBI-10192441, EBI-10173151;
CC Q86VR2; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-10192441, EBI-347385;
CC Q86VR2; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10192441, EBI-10982110;
CC Q86VR2; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-10192441, EBI-11528917;
CC Q86VR2; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-10192441, EBI-12887458;
CC Q86VR2; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-10192441, EBI-11956809;
CC Q86VR2; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-10192441, EBI-12038591;
CC Q86VR2; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-10192441, EBI-2852148;
CC Q86VR2; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-10192441, EBI-6656213;
CC Q86VR2; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-10192441, EBI-11724433;
CC Q86VR2; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-10192441, EBI-17249488;
CC Q86VR2; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-10192441, EBI-12003468;
CC Q86VR2; Q5TGU0: TSPO2; NbExp=5; IntAct=EBI-10192441, EBI-12195249;
CC Q86VR2; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-10192441, EBI-2819725;
CC Q86VR2; P23763-3: VAMP1; NbExp=3; IntAct=EBI-10192441, EBI-12097582;
CC Q86VR2; Q15836: VAMP3; NbExp=3; IntAct=EBI-10192441, EBI-722343;
CC Q86VR2; O75379: VAMP4; NbExp=3; IntAct=EBI-10192441, EBI-744953;
CC Q86VR2; O95183: VAMP5; NbExp=3; IntAct=EBI-10192441, EBI-10191195;
CC Q86VR2; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-10192441, EBI-1059156;
CC Q86VR2; O95292: VAPB; NbExp=3; IntAct=EBI-10192441, EBI-1188298;
CC Q86VR2; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-10192441, EBI-7850136;
CC Q86VR2; Q96EC8: YIPF6; NbExp=5; IntAct=EBI-10192441, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86VR2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86VR2-2; Sequence=VSP_056991;
CC -!- DOMAIN: The LIR motif interacts with ATG8 family proteins.
CC {ECO:0000269|PubMed:26040720}.
CC -!- SIMILARITY: Belongs to the RETREG family. {ECO:0000305}.
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DR EMBL; AK091125; BAG52287.1; -; mRNA.
DR EMBL; AK294791; BAG57914.1; -; mRNA.
DR EMBL; AC067852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60851.1; -; Genomic_DNA.
DR EMBL; BC049370; AAH49370.1; -; mRNA.
DR CCDS; CCDS11432.1; -. [Q86VR2-1]
DR RefSeq; NP_835227.1; NM_178126.3. [Q86VR2-1]
DR AlphaFoldDB; Q86VR2; -.
DR BioGRID; 127817; 231.
DR DIP; DIP-61578N; -.
DR IntAct; Q86VR2; 160.
DR MINT; Q86VR2; -.
DR STRING; 9606.ENSP00000309432; -.
DR iPTMnet; Q86VR2; -.
DR PhosphoSitePlus; Q86VR2; -.
DR SwissPalm; Q86VR2; -.
DR BioMuta; RETREG3; -.
DR DMDM; 74727607; -.
DR EPD; Q86VR2; -.
DR jPOST; Q86VR2; -.
DR MassIVE; Q86VR2; -.
DR MaxQB; Q86VR2; -.
DR PaxDb; Q86VR2; -.
DR PeptideAtlas; Q86VR2; -.
DR PRIDE; Q86VR2; -.
DR ProteomicsDB; 3584; -.
DR ProteomicsDB; 70060; -. [Q86VR2-1]
DR Antibodypedia; 3087; 71 antibodies from 17 providers.
DR DNASU; 162427; -.
DR Ensembl; ENST00000309428.10; ENSP00000309432.4; ENSG00000141699.11. [Q86VR2-1]
DR GeneID; 162427; -.
DR KEGG; hsa:162427; -.
DR MANE-Select; ENST00000309428.10; ENSP00000309432.4; NM_178126.4; NP_835227.1.
DR UCSC; uc060fkv.1; human. [Q86VR2-1]
DR CTD; 162427; -.
DR DisGeNET; 162427; -.
DR GeneCards; RETREG3; -.
DR HGNC; HGNC:27258; RETREG3.
DR HPA; ENSG00000141699; Low tissue specificity.
DR MIM; 616498; gene.
DR neXtProt; NX_Q86VR2; -.
DR OpenTargets; ENSG00000141699; -.
DR PharmGKB; PA162386207; -.
DR VEuPathDB; HostDB:ENSG00000141699; -.
DR eggNOG; ENOG502QPTN; Eukaryota.
DR GeneTree; ENSGT00940000161349; -.
DR HOGENOM; CLU_036265_0_0_1; -.
DR InParanoid; Q86VR2; -.
DR OMA; HIAEAWV; -.
DR OrthoDB; 901531at2759; -.
DR PhylomeDB; Q86VR2; -.
DR TreeFam; TF329111; -.
DR PathwayCommons; Q86VR2; -.
DR SignaLink; Q86VR2; -.
DR SIGNOR; Q86VR2; -.
DR BioGRID-ORCS; 162427; 21 hits in 1088 CRISPR screens.
DR ChiTaRS; FAM134C; human.
DR GeneWiki; FAM134C; -.
DR GenomeRNAi; 162427; -.
DR Pharos; Q86VR2; Tdark.
DR PRO; PR:Q86VR2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q86VR2; protein.
DR Bgee; ENSG00000141699; Expressed in parotid gland and 209 other tissues.
DR ExpressionAtlas; Q86VR2; baseline and differential.
DR Genevisible; Q86VR2; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0140506; F:endoplasmic reticulum-autophagosome adaptor activity; IEA:Ensembl.
DR GO; GO:0030574; P:collagen catabolic process; IEA:Ensembl.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IMP:UniProtKB.
DR GO; GO:0061709; P:reticulophagy; IEA:Ensembl.
DR InterPro; IPR043384; RETREG1/3.
DR InterPro; IPR033361; RETREG3.
DR PANTHER; PTHR28659; PTHR28659; 1.
DR PANTHER; PTHR28659:SF1; PTHR28659:SF1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22814378"
FT CHAIN 2..466
FT /note="Reticulophagy regulator 3"
FT /id="PRO_0000288469"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 445..450
FT /note="LIR motif"
FT /evidence="ECO:0000305|PubMed:26040720"
FT COMPBIAS 292..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22814378"
FT MOD_RES 10
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 258
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 260
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 283
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQV4"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQV4"
FT MOD_RES 303
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQV4"
FT MOD_RES 307
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569"
FT MOD_RES 310
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
FT MOD_RES 360
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 440
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332"
FT VAR_SEQ 1..195
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056991"
SQ SEQUENCE 466 AA; 51396 MW; F9D468353C13A14B CRC64;
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE PLLSRVQAAL
VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII VCIDQWKNKI WPEIKVPRPD
ALDNESWGFV HPRLLSVPEL CHHVAEVWVS GTIFIRNVLL FKKQNPGKFC LLSCGILTFL
AVLGRYVPGL LLSYLMLVTV MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE
RQLRRRALHP ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS IGMPSLMYRS
PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL VSQGMIQLAL SGASQPGPSG
APAQRATRGF LRSPSSDLDT DAEGDDFELL DQSELSQLDP ASSRSH