ID   RETR3_XENTR             Reviewed;         457 AA.
AC   Q0P4Z1; Q07G99;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Reticulophagy regulator 3;
GN   Name=retreg3; Synonyms=fam134c; ORFNames=TNeu105l15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with ATG8 family modifier proteins.
CC       {ECO:0000250|UniProtKB:Q86VR2}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: The LIR motif interacts with ATG8 family proteins.
CC       {ECO:0000250|UniProtKB:Q86VR2}.
CC   -!- SIMILARITY: Belongs to the RETREG family. {ECO:0000305}.
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DR   EMBL; CR760241; CAL49403.1; -; mRNA.
DR   EMBL; BC121834; AAI21835.1; -; mRNA.
DR   RefSeq; NP_001016672.2; NM_001016672.3.
DR   RefSeq; XP_012809972.1; XM_012954518.2.
DR   AlphaFoldDB; Q0P4Z1; -.
DR   PaxDb; Q0P4Z1; -.
DR   DNASU; 549426; -.
DR   GeneID; 549426; -.
DR   KEGG; xtr:549426; -.
DR   CTD; 162427; -.
DR   Xenbase; XB-GENE-5719860; retreg3.
DR   eggNOG; ENOG502QPTN; Eukaryota.
DR   InParanoid; Q0P4Z1; -.
DR   OrthoDB; 901531at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014893; Expressed in skeletal muscle tissue and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IEA:InterPro.
DR   GO; GO:0061709; P:reticulophagy; IEA:InterPro.
DR   InterPro; IPR043384; RETREG1/3.
DR   InterPro; IPR033361; RETREG3.
DR   PANTHER; PTHR28659; PTHR28659; 1.
DR   PANTHER; PTHR28659:SF1; PTHR28659:SF1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..457
FT                   /note="Reticulophagy regulator 3"
FT                   /id="PRO_0000288471"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          291..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           435..440
FT                   /note="LIR motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6L5"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..323
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        421
FT                   /note="Q -> R (in Ref. 1; CAL49403)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   457 AA;  51364 MW;  1351C6D711AC2585 CRC64;
     MAQRVGEEEQ GASGLRRRRS GARCVEARER DEQVREVQEM LQRGLSSYEP VLSYVQAVLV
     WERPRHSALL HLALNAAFWF FALTSLRIIF LVAFGLMIII CADQWKNKLW PELGAARASE
     LENESWGYVH PRLLSVPELC YHAADTWVSV YNFLRNLLLF KTENPGKFCL LACSFLTFLA
     VLGGYIPGVV LSYLLLLFLL LWPLAIYHQL GRRIYQKLEP ALQRLDFSVR GYMMSKYKER
     QKHNRALPPT DASDSEEELA AFCPSLDDSA VAKELTISDS EHSDAEVSFT ENGTFNLSRG
     QTPLTEGSED LDRHSDPEES FARDLPDFPS INPDATGIED DDETSIGIPS TALHPQFSSR
     QLYEEQESLD AELSLGGFPS TQNITENIAG FVTRGMIQLA LAGASQQTHA YAESPRAKQY
     QRNSSSELDT DAEADDFELL DQSELSQMDP SSSHSHQ