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REV7_SCHPO
ID   REV7_SCHPO              Reviewed;         213 AA.
AC   Q0E7J8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=DNA polymerase zeta processivity subunit;
DE   AltName: Full=Revertibility protein 7 {ECO:0000250|UniProtKB:P38927};
GN   Name=rev7; ORFNames=SPAC12D12.09, SPBC12D12.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAL45666.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for DNA damage induced mutagenesis. Involved in DNA
CC       repair, mitochondrial DNA repair and translesion synthesis. Has a role
CC       in the bypass of abasic (AP) sites (By similarity).
CC       {ECO:0000250|UniProtKB:P38927}.
CC   -!- SUBUNIT: Forms DNA polymerase zeta with rev3.
CC       {ECO:0000250|UniProtKB:P38927}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC       Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the MAD2 family. {ECO:0000255}.
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DR   EMBL; CU329671; CAL45666.1; -; Genomic_DNA.
DR   RefSeq; XP_001713135.1; XM_001713083.2.
DR   AlphaFoldDB; Q0E7J8; -.
DR   SMR; Q0E7J8; -.
DR   BioGRID; 276643; 14.
DR   IntAct; Q0E7J8; 1.
DR   STRING; 4896.SPBC12D12.09.1; -.
DR   PaxDb; Q0E7J8; -.
DR   EnsemblFungi; SPBC12D12.09.1; SPBC12D12.09.1:pep; SPBC12D12.09.
DR   PomBase; SPBC12D12.09; rev7.
DR   VEuPathDB; FungiDB:SPBC12D12.09; -.
DR   eggNOG; KOG3186; Eukaryota.
DR   HOGENOM; CLU_050394_1_1_1; -.
DR   InParanoid; Q0E7J8; -.
DR   OMA; DEASHEC; -.
DR   Reactome; R-SPO-110312; Translesion synthesis by REV1.
DR   Reactome; R-SPO-5655862; Translesion synthesis by POLK.
DR   Reactome; R-SPO-5656121; Translesion synthesis by POLI.
DR   PRO; PR:Q0E7J8; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000262; C:mitochondrial chromosome; IC:PomBase.
DR   GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; ISO:PomBase.
DR   GO; GO:0070987; P:error-free translesion synthesis; ISO:PomBase.
DR   GO; GO:0042276; P:error-prone translesion synthesis; ISO:PomBase.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IC:PomBase.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR003511; HORMA_dom.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   InterPro; IPR045091; Mad2-like.
DR   PANTHER; PTHR11842; PTHR11842; 1.
DR   Pfam; PF02301; HORMA; 1.
DR   SUPFAM; SSF56019; SSF56019; 1.
DR   PROSITE; PS50815; HORMA; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..213
FT                   /note="DNA polymerase zeta processivity subunit"
FT                   /id="PRO_0000361056"
FT   DOMAIN          10..206
FT                   /note="HORMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
SQ   SEQUENCE   213 AA;  25038 MW;  EB42AE999B55549A CRC64;
     MENDTGWSVK KCIDIFGEFL LVSIHCILYA RRLYPQDLFI KARKYNTIVW QSRHPILCEY
     IEEVVQSCIE ELQTGSVHQV ALSIINKEQR EEERYVFSTD SIPIIPDFLL EKQISTNEPF
     TDAYVEYMRA SLIQLLNITN GLPLIEQECT WTLRVTLKDG FPRPKQWEEW FLPPQARETD
     ATRQFKGITI PVRNVDIGPM MTEIWVEKYT NSD
 
 
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