REV7_YEAST
ID REV7_YEAST Reviewed; 245 AA.
AC P38927; D6VVE7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=DNA polymerase zeta processivity subunit;
DE AltName: Full=Revertibility protein 7;
GN Name=REV7; OrderedLocusNames=YIL139C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=7871890; DOI=10.1002/yea.320101115;
RA Torpey L.E., Gibbs P.E.M., Nelson J., Lawrence C.W.;
RT "Cloning and sequence of REV7, a gene whose function is required for DNA
RT damage-induced mutagenesis in Saccharomyces cerevisiae.";
RL Yeast 10:1503-1509(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND INTERACTION WITH REV3.
RX PubMed=8658138; DOI=10.1126/science.272.5268.1646;
RA Nelson J.R., Lawrence C.W., Hinkle D.C.;
RT "Thymine-thymine dimer bypass by yeast DNA polymerase zeta.";
RL Science 272:1646-1649(1996).
RN [5]
RP FUNCTION.
RX PubMed=11316789; DOI=10.1101/gad.882301;
RA Haracska L., Unk I., Johnson R.E., Johansson E., Burgers P.M.J.,
RA Prakash S., Prakash L.;
RT "Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of
RT abasic sites.";
RL Genes Dev. 15:945-954(2001).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16452144; DOI=10.1534/genetics.105.051029;
RA Zhang H., Chatterjee A., Singh K.K.;
RT "Saccharomyces cerevisiae polymerase zeta functions in mitochondria.";
RL Genetics 172:2683-2688(2006).
RN [7]
RP INTERACTION WITH REV1.
RX PubMed=18242152; DOI=10.1016/j.dnarep.2007.11.016;
RA Kosarek J.N., Woodruff R.V., Rivera-Begeman A., Guo C., D'Souza S.,
RA Koonin E.V., Walker G.C., Friedberg E.C.;
RT "Comparative analysis of in vivo interactions between Rev1 protein and
RT other Y-family DNA polymerases in animals and yeasts.";
RL DNA Repair 7:439-451(2008).
CC -!- FUNCTION: Required for DNA damage induced mutagenesis. Involved in DNA
CC repair, mitochondrial DNA repair and translesion synthesis. Has a role
CC in the bypass of abasic (AP) sites. {ECO:0000269|PubMed:11316789,
CC ECO:0000269|PubMed:16452144, ECO:0000269|PubMed:7871890,
CC ECO:0000269|PubMed:8658138}.
CC -!- SUBUNIT: Forms DNA polymerase zeta with REV3 (PubMed:8658138).
CC Interacts with REV1 (PubMed:18242152). {ECO:0000269|PubMed:18242152,
CC ECO:0000269|PubMed:8658138}.
CC -!- INTERACTION:
CC P38927; Q08949: DDC1; NbExp=3; IntAct=EBI-14960, EBI-30769;
CC P38927; Q02574: MEC3; NbExp=3; IntAct=EBI-14960, EBI-10658;
CC P38927; P12689: REV1; NbExp=3; IntAct=EBI-14960, EBI-14951;
CC P38927; P14284: REV3; NbExp=3; IntAct=EBI-14960, EBI-6155;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16452144}.
CC -!- SIMILARITY: Belongs to the MAD2 family. {ECO:0000305}.
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DR EMBL; Z38059; CAA86139.1; -; Genomic_DNA.
DR EMBL; U07228; AAA67918.1; -; Genomic_DNA.
DR EMBL; U49845; AAA98667.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08413.1; -; Genomic_DNA.
DR PIR; S48395; S48395.
DR RefSeq; NP_012127.1; NM_001179487.1.
DR PDB; 6V8P; EM; 4.10 A; D/E=1-245.
DR PDB; 6V93; EM; 3.10 A; D/E=1-245.
DR PDB; 7LXD; EM; 4.11 A; D/E=1-245.
DR PDB; 7S0T; EM; 3.05 A; D/E=1-245.
DR PDBsum; 6V8P; -.
DR PDBsum; 6V93; -.
DR PDBsum; 7LXD; -.
DR PDBsum; 7S0T; -.
DR AlphaFoldDB; P38927; -.
DR SMR; P38927; -.
DR BioGRID; 34852; 81.
DR ComplexPortal; CPX-1091; DNA polymerase zeta complex.
DR DIP; DIP-819N; -.
DR IntAct; P38927; 6.
DR STRING; 4932.YIL139C; -.
DR iPTMnet; P38927; -.
DR PaxDb; P38927; -.
DR PRIDE; P38927; -.
DR EnsemblFungi; YIL139C_mRNA; YIL139C; YIL139C.
DR GeneID; 854667; -.
DR KEGG; sce:YIL139C; -.
DR SGD; S000001401; REV7.
DR VEuPathDB; FungiDB:YIL139C; -.
DR eggNOG; ENOG502QZWG; Eukaryota.
DR HOGENOM; CLU_1129615_0_0_1; -.
DR InParanoid; P38927; -.
DR OMA; VLYYRNV; -.
DR BioCyc; YEAST:G3O-31390-MON; -.
DR Reactome; R-SCE-110312; Translesion synthesis by REV1.
DR Reactome; R-SCE-5655862; Translesion synthesis by POLK.
DR Reactome; R-SCE-5656121; Translesion synthesis by POLI.
DR SABIO-RK; P38927; -.
DR PRO; PR:P38927; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P38927; protein.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IDA:SGD.
DR GO; GO:0070987; P:error-free translesion synthesis; IDA:SGD.
DR GO; GO:0042276; P:error-prone translesion synthesis; IDA:SGD.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR InterPro; IPR045091; Mad2-like.
DR PANTHER; PTHR11842; PTHR11842; 1.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA repair; Mitochondrion; Reference proteome.
FT CHAIN 1..245
FT /note="DNA polymerase zeta processivity subunit"
FT /id="PRO_0000126116"
FT DOMAIN 3..203
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT HELIX 2..23
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 35..41
FT /evidence="ECO:0007829|PDB:6V93"
FT HELIX 52..67
FT /evidence="ECO:0007829|PDB:6V93"
FT TURN 68..71
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 73..81
FT /evidence="ECO:0007829|PDB:6V93"
FT TURN 82..84
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 87..94
FT /evidence="ECO:0007829|PDB:6V93"
FT HELIX 110..128
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 139..146
FT /evidence="ECO:0007829|PDB:6V93"
FT HELIX 165..174
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 175..179
FT /evidence="ECO:0007829|PDB:6V93"
FT STRAND 212..216
FT /evidence="ECO:0007829|PDB:6V93"
SQ SEQUENCE 245 AA; 28760 MW; 325668130CD13259 CRC64;
MNRWVEKWLR VYLKCYINLI LFYRNVYPPQ SFDYTTYQSF NLPQFVPINR HPALIDYIEE
LILDVLSKLT HVYRFSICII NKKNDLCIEK YVLDFSELQH VDKDDQIITE TEVFDEFRSS
LNSLIMHLEK LPKVNDDTIT FEAVINAIEL ELGHKLDRNR RVDSLEEKAE IERDSNWVKC
QEDENLPDNN GFQPPKIKLT SLVGSDVGPL IIHQFSEKLI SGDDKILNGV YSQYEEGESI
FGSLF
