ID   REV_CAEV                Reviewed;         133 AA.
AC   P31628;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   02-JUN-2021, entry version 42.
DE   RecName: Full=Protein Rev;
DE   AltName: Full=Rev-C;
GN   Name=rev;
OS   Caprine arthritis encephalitis virus (CAEV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11660;
OH   NCBI_TaxID=9925; Capra hircus (Goat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1649509; DOI=10.1016/0042-6822(91)91012-6;
RA   Kalinski H., Yaniv A., Mashiah P., Miki T., Tronick S.R., Gazit A.;
RT   "rev-like transcripts of caprine arthritis encephalitis virus.";
RL   Virology 183:786-792(1991).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus {ECO:0000250}. Host
CC       cytoplasm {ECO:0000250}. Note=The presence of both nuclear import and
CC       nuclear export signals leads to continuous shuttling between the
CC       nucleus and cytoplasm. {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE present in incompletely
CC       spliced viral pre-mRNAs. This region also contains the NLS which
CC       mediates nuclear localization. These overlapping functions prevent Rev
CC       bound to RRE from undesirable return to the nucleus. When Rev binds the
CC       RRE, the NLS becomes masked while the NES remains accessible (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; M63105; AAA42893.1; -; mRNA.
DR   PIR; A40479; VKLJCE.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT   CHAIN           1..133
FT                   /note="Protein Rev"
FT                   /id="PRO_0000085474"
FT   REGION          13..27
FT                   /note="RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   REGION          42..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           59..82
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           89..102
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   133 AA;  15267 MW;  ED64EA0840BFB158 CRC64;
     MDAGARQIRF TGEKNWMEVT MEEEEKGKRK GCIERQQDIQ DLKYPNLPAG HSHHGNKSRR
     RRRQSGFWRW LRGIRRQRDK PKGDSEKGLG SCVGALAELT LEEAMAEEPA DAASPTADDG
     HLDKWTAWRL PQK