ID   REV_FIVPE               Reviewed;         151 AA.
AC   P20885;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   23-FEB-2022, entry version 55.
DE   RecName: Full=Probable protein Rev;
DE   AltName: Full=3'ORF;
DE   AltName: Full=ART/TRS;
DE   AltName: Full=Anti-repression transactivator;
DE   AltName: Full=ORF4;
DE   AltName: Full=ORFH;
DE   AltName: Full=Regulator of expression of viral proteins;
GN   Name=rev;
OS   Feline immunodeficiency virus (isolate Petaluma) (FIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11674;
OH   NCBI_TaxID=9681; Felidae (cat family).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Clone 34TF10;
RX   PubMed=2762293; DOI=10.1073/pnas.86.15.5743;
RA   Talbott R.L., Sparger E.E., Lovelace K.M., Fitch W.M., Pedersen N.C.,
RA   Luciw P.A., Elder J.H.;
RT   "Nucleotide sequence and genomic organization of feline immunodeficiency
RT   virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5743-5747(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Clone FIV-14;
RX   PubMed=2813380; DOI=10.1073/pnas.86.20.8088;
RA   Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.;
RT   "Nucleotide sequence analysis of feline immunodeficiency virus: genome
RT   organization and relationship to other lentiviruses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8088-8092(1989).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC       Note=The presence of both nuclear import and nuclear export signals
CC       leads to continuous shuttling between the nucleus and cytoplasm.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC       structure present in incompletely spliced viral pre-mRNAs. This region
CC       also contains the NLS which mediates nuclear localization. These
CC       overlapping functions prevent Rev bound to RRE from undesirable return
CC       to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC       the NES remains accessible (By similarity). {ECO:0000250}.
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DR   EMBL; M25381; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; E33543; ASLJF2.
DR   SMR; P20885; -.
DR   Proteomes; UP000242267; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018582; Envelope_glycop_lentivirus.
DR   Pfam; PF09590; Env-gp36; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; mRNA transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..151
FT                   /note="Probable protein Rev"
FT                   /id="PRO_0000085515"
FT   REGION          108..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           84..93
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        122..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   151 AA;  17823 MW;  7385591B0591B119 CRC64;
     MAEGFAANRQ WIGLEEAEEL LDFDIATQMS EEGPLNPGVN PFRVPGITEK EKQNYCNILQ
     PKLQDLRNEI QEVKLEEGNA GKRKRQRRRR KKKAFKRMMT ELEDRFRKLF GTTSTTGDST
     VDSEDEPPKK EKRVDWDEYW NPEEIERMLM D