ID   REV_FIVSD               Reviewed;         153 AA.
AC   P19032; Q90068;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   23-FEB-2022, entry version 49.
DE   RecName: Full=Probable protein Rev;
DE   AltName: Full=3'ORF;
DE   AltName: Full=ART/TRS;
DE   AltName: Full=Anti-repression transactivator;
DE   AltName: Full=ORF4;
DE   AltName: Full=ORFH;
DE   AltName: Full=Regulator of expression of viral proteins;
GN   Name=rev;
OS   Feline immunodeficiency virus (strain San Diego) (FIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11675;
OH   NCBI_TaxID=9681; Felidae (cat family).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate PPR;
RX   PubMed=1697907; DOI=10.1128/jvi.64.10.4605-4613.1990;
RA   Phillips T.R., Talbott R.L., Lamont C., Muir S., Lovelace K.M., Elder J.H.;
RT   "Comparison of two host cell range variants of feline immunodeficiency
RT   virus.";
RL   J. Virol. 64:4605-4613(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1323707; DOI=10.1128/jvi.66.9.5464-5471.1992;
RA   Phillips T.R., Lamont C., Konings D.A.M., Shacklett B.L., Hamson C.A.,
RA   Luciw P.A., Elder J.H.;
RT   "Identification of the Rev transactivation and Rev-responsive elements of
RT   feline immunodeficiency virus.";
RL   J. Virol. 66:5464-5471(1992).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC       Note=The presence of both nuclear import and nuclear export signals
CC       leads to continuous shuttling between the nucleus and cytoplasm.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC       structure present in incompletely spliced viral pre-mRNAs. This region
CC       also contains the NLS which mediates nuclear localization. These
CC       overlapping functions prevent Rev bound to RRE from undesirable return
CC       to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC       the NES remains accessible (By similarity). {ECO:0000250}.
CC   -!- CAUTION: PubMed:1323707 sequence does not seem to originate from
CC       isolate Petaluma as described, but rather from the strain San Diego.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA43081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M36968; AAA43081.1; ALT_SEQ; Genomic_RNA.
DR   EMBL; S42322; AAB22932.1; -; mRNA.
DR   PIR; B42748; B42748.
DR   SMR; P19032; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018582; Envelope_glycop_lentivirus.
DR   Pfam; PF09590; Env-gp36; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT   CHAIN           1..153
FT                   /note="Probable protein Rev"
FT                   /id="PRO_0000085514"
FT   REGION          24..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           84..95
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   153 AA;  18279 MW;  7DA5D8BF1EDC4F7A CRC64;
     MAEGFAANRQ WIGPEEAEEL LDFDKATQMN EEGPLNPGVN PFRVPAVTEA DKQEYCKILQ
     PRLQEIRNEI QEVKLEEGNA GKMKKKRQRR RRKKKAFKKM MTDLEDRFRK LFGSPSKDEY
     TEIEIEEDPP KKEKRVDWDE YWDPEEIERM LMD