REV_HV2NZ
ID REV_HV2NZ Reviewed; 107 AA.
AC P05873;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 02-JUN-2021, entry version 74.
DE RecName: Full=Protein Rev;
DE AltName: Full=Regulator of expression of viral proteins;
GN Name=rev;
OS Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11719;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3261862; DOI=10.1073/pnas.85.16.5941;
RA Zagury J.F., Franchini G., Reitz M.S. Jr., Collalti E., Starcich B.R.,
RA Hall L., Fargnoli K.A., Jagodzinski L.L., Guo H.-G., Laure F., Arya S.K.,
RA Josephs S.F., Zagury D., Wong-Staal F., Gallo R.C.;
RT "Genetic variability between isolates of human immunodeficiency virus (HIV)
RT type 2 is comparable to the variability among HIV type 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:5941-5945(1988).
CC -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC (late transcripts) out of the nucleus of infected cells. These pre-
CC mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC located in the env gene, that is not present in fully spliced viral
CC mRNAs (early transcripts). This function is essential since most viral
CC proteins are translated from unspliced or partially spliced pre-mRNAs
CC which cannot exit the nucleus by the pathway used by fully processed
CC cellular mRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC essential for activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC Note=The presence of both nuclear import and nuclear export signals
CC leads to continuous shuttling between the nucleus and cytoplasm.
CC {ECO:0000250}.
CC -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC structure present in incompletely spliced viral pre-mRNAs. This region
CC also contains the NLS which mediates nuclear localization. These
CC overlapping functions prevent Rev bound to RRE from undesirable return
CC to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC the NES remains accessible (By similarity). {ECO:0000250}.
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DR EMBL; J03654; AAB00760.1; -; Genomic_DNA.
DR SMR; P05873; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR InterPro; IPR000625; REV_protein.
DR Pfam; PF00424; REV; 1.
PE 3: Inferred from homology;
KW AIDS; Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT CHAIN 1..107
FT /note="Protein Rev"
FT /id="PRO_0000085288"
FT REGION 16..24
FT /note="Homomultimerization"
FT /evidence="ECO:0000250"
FT REGION 21..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 35..49
FT /note="Nuclear localization signal and RNA-binding (RRE)"
FT /evidence="ECO:0000250"
FT MOTIF 71..82
FT /note="Nuclear export signal and binding to XPO1"
FT /evidence="ECO:0000250"
FT COMPBIAS 93..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 107 AA; 12374 MW; 7B2341DF1AA304C1 CRC64;
MTERADEEGL QRKLRLIRLL HQTNPYPQGP GTASQRRNRR RRWKQRWRQI LALADSIYTF
PDPPADSPLD RAIQHLQGLT IQDLPDPPTN LPESPESTNS NQRLAEA
