ID   REV_HV2RO               Reviewed;         100 AA.
AC   P04615;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   02-JUN-2021, entry version 85.
DE   RecName: Full=Protein Rev;
DE   AltName: Full=Regulator of expression of viral proteins;
GN   Name=rev;
OS   Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11720;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031510; DOI=10.1038/326662a0;
RA   Guyader M., Emerman M., Sonigo P., Clavel F., Montagnier L., Alizon M.;
RT   "Genome organization and transactivation of the human immunodeficiency
RT   virus type 2.";
RL   Nature 326:662-669(1987).
RN   [2]
RP   FUNCTION.
RX   PubMed=2200888; DOI=10.1128/jvi.64.9.4428-4437.1990;
RA   Dillon P.J., Nelbock P., Perkins A., Rosen C.A.;
RT   "Function of the human immunodeficiency virus types 1 and 2 Rev proteins is
RT   dependent on their ability to interact with a structured region present in
RT   env gene mRNA.";
RL   J. Virol. 64:4428-4437(1990).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:2200888}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC       Note=The presence of both nuclear import and nuclear export signals
CC       leads to continuous shuttling between the nucleus and cytoplasm.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC       structure present in incompletely spliced viral pre-mRNAs. This region
CC       also contains the NLS which mediates nuclear localization. These
CC       overlapping functions prevent Rev bound to RRE from undesirable return
CC       to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC       the NES remains accessible (By similarity). {ECO:0000250}.
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DR   EMBL; M15390; AAB00769.1; -; Genomic_DNA.
DR   EMBL; X05291; CAA28913.1; -; Genomic_RNA.
DR   PIR; F26262; VKLJG2.
DR   SMR; P04615; -.
DR   Proteomes; UP000007426; Genome.
DR   Proteomes; UP000246871; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000625; REV_protein.
DR   Pfam; PF00424; REV; 1.
PE   3: Inferred from homology;
KW   AIDS; Host cytoplasm; Host nucleus; mRNA transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..100
FT                   /note="Protein Rev"
FT                   /id="PRO_0000085289"
FT   REGION          16..24
FT                   /note="Homomultimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          22..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           35..49
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           71..82
FT                   /note="Nuclear export signal and binding to XPO1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  11726 MW;  14D4DF2E4564AC00 CRC64;
     MNERADEEGL QRKLRLIRLL HQTNPYPQGP GTASQRRNRR RRWKQRWRQI LALADSIYTF
     PDPPADSPLD QTIQHLQGLT IQELPDPPTH LPESQRLAET