ID   REV_JEMBR               Reviewed;         213 AA.
AC   Q82855; Q82856;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 54.
DE   RecName: Full=Protein Rev;
GN   Name=rev;
OS   Jembrana disease virus (JDV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=36370;
OH   NCBI_TaxID=9906; Bos javanicus (Wild banteng).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] (ISOFORMS LONG AND SHORT).
RC   STRAIN=Tabanan/87;
RX   PubMed=9049370; DOI=10.1099/0022-1317-76-7-1637;
RA   Chadwick B.J., Coelen R.J., Wilcox G.E., Sammels L.M., Kertayadnya G.;
RT   "Nucleotide sequence analysis of Jembrana disease virus: a bovine
RT   lentivirus associated with an acute disease syndrome.";
RL   J. Gen. Virol. 76:1637-1650(1995).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus {ECO:0000250}. Host
CC       cytoplasm {ECO:0000250}. Note=The presence of both nuclear import and
CC       nuclear export signals leads to continuous shuttling between the
CC       nucleus and cytoplasm. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=Q82855-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=Q82855-2; Sequence=VSP_022397;
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE present in incompletely
CC       spliced viral pre-mRNAs. This region also contains the NLS which
CC       mediates nuclear localization. These overlapping functions prevent Rev
CC       bound to RRE from undesirable return to the nucleus. When Rev binds the
CC       RRE, the NLS becomes masked while the NES remains accessible (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated.
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DR   EMBL; U21603; AAA64393.1; -; Genomic_RNA.
DR   EMBL; U21603; AAA64396.1; -; Genomic_RNA.
DR   SMR; Q82855; -.
DR   Proteomes; UP000246436; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008411; BIV_Surface_Envelope.
DR   Pfam; PF05858; BIV_Env; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; Host cytoplasm; Host nucleus;
KW   mRNA transport; Phosphoprotein; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..213
FT                   /note="Protein Rev"
FT                   /id="PRO_0000272360"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          97..131
FT                   /evidence="ECO:0000255"
FT   MOTIF           80..104
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           109..122
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         36..47
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_022397"
SQ   SEQUENCE   213 AA;  23780 MW;  7C9A6A167B0471DD CRC64;
     MMEEGRKEEP EERGEKSTMR DLLQRAVDKG HLTAREALDR WTLEDHGPPV HHVKLGRSNT
     VSIAECARGY RPCRGRRPAR RPPIRRHPSF WGTLRGLVSE AQRRQEDRMS DLENRMAELE
     ERFEDLALVD SGGKNPAAPA QSVSPPSSNP FAYSLSHFSK SKRVDCGEKG NRWGRPGAFP
     GAGISELDWI ESGDGGDERP KGGRYPRGGN TPS