REV_OMVVS
ID REV_OMVVS Reviewed; 144 AA.
AC P16903;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 02-JUN-2021, entry version 58.
DE RecName: Full=Protein Rev;
GN Name=rev;
OS Ovine maedi visna related virus (strain South Africa) (SA-OMVV) (Ovine
OS lentivirus).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11664;
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2158181; DOI=10.1016/0042-6822(90)90428-t;
RA Querat G., Audoly G., Sonigo P., Vigne R.;
RT "Nucleotide sequence analysis of SA-OMVV, a visna-related ovine lentivirus:
RT phylogenetic history of lentiviruses.";
RL Virology 175:434-447(1990).
CC -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC (late transcripts) out of the nucleus of infected cells. These pre-
CC mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC located in the env gene, that is not present in fully spliced viral
CC mRNAs (early transcripts). This function is essential since most viral
CC proteins are translated from unspliced or partially spliced pre-mRNAs
CC which cannot exit the nucleus by the pathway used by fully processed
CC cellular mRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC essential for activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus {ECO:0000250}. Host
CC cytoplasm {ECO:0000250}. Note=The presence of both nuclear import and
CC nuclear export signals leads to continuous shuttling between the
CC nucleus and cytoplasm. {ECO:0000250}.
CC -!- DOMAIN: The RNA-binding motif binds to the RRE present in incompletely
CC spliced viral pre-mRNAs. This region also contains the NLS which
CC mediates nuclear localization. These overlapping functions prevent Rev
CC bound to RRE from undesirable return to the nucleus. When Rev binds the
CC RRE, the NLS becomes masked while the NES remains accessible (By
CC similarity). {ECO:0000250}.
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DR EMBL; M31646; AAA66816.1; -; Genomic_RNA.
DR EMBL; M34193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P16903; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR InterPro; IPR016400; Rev_lentivir.
DR PIRSF; PIRSF003867; Rev_lenti-OC; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT CHAIN 1..144
FT /note="Protein Rev"
FT /id="PRO_0000085480"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 75..92
FT /note="Nuclear localization signal and RNA-binding (RRE)"
FT /evidence="ECO:0000250"
FT MOTIF 106..115
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 16547 MW; 3B7B34E7F0611F2E CRC64;
MASSKNMPSR ITQKSMEPPL RETWQQVVQE MVMRKQRDEE EKQNLVTGLQ ASSGDPIYTG
NSSDRSTRGP GGKTKRRKGW FQWLRKLRAR EKNIPSQFYP DMEGNCAGLE NLTLGEGMEE
NPIYDSTAAT NTANMDGRNW MEWR
