ID   REV_SIVG1               Reviewed;         147 AA.
AC   Q02839;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   02-JUN-2021, entry version 68.
DE   RecName: Full=Protein Rev;
DE   AltName: Full=Regulator of expression of viral proteins;
GN   Name=rev;
OS   Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri)
OS   (Simian immunodeficiency virus African green monkey grivet).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=31684;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2024476; DOI=10.1016/0042-6822(91)90689-9;
RA   Fomsgaard A., Hirsch V.M., Allan J.S., Johnson P.R.;
RT   "A highly divergent proviral DNA clone of SIV from a distinct species of
RT   African green monkey.";
RL   Virology 182:397-402(1991).
RN   [2]
RP   SEQUENCE REVISION TO 21-22.
RA   Fomsgaard A., Hirsch V.M., Allan J.S., Johnson P.R.;
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC       Note=The presence of both nuclear import and nuclear export signals
CC       leads to continuous shuttling between the nucleus and cytoplasm.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC       structure present in incompletely spliced viral pre-mRNAs. This region
CC       also contains the NLS which mediates nuclear localization. These
CC       overlapping functions prevent Rev bound to RRE from undesirable return
CC       to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC       the NES remains accessible (By similarity). {ECO:0000250}.
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DR   EMBL; M66437; AAA91927.2; -; Genomic_DNA.
DR   EMBL; M58410; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; Q02839; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000625; REV_protein.
DR   Pfam; PF00424; REV; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT   CHAIN           1..147
FT                   /note="Protein Rev"
FT                   /id="PRO_0000085293"
FT   REGION          13..21
FT                   /note="Homomultimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          24..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           29..45
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           70..82
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        106..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   147 AA;  16358 MW;  B4822209ECA5506E CRC64;
     MSLGKEEKQA LKIIKTLYGS NPYPQFSGTA RQRRRARQRW RKQQQQIDKI AGRVLNTFED
     QQLVAQLQEL QLENKDLVLQ HLPDPPHIHQ DSSGIPAVWA PATPRGSNRA CSSSGEGCEG
     SLGQTGCYCP IRLSGSHQQS KKSAARP