REV_SIVML
ID REV_SIVML Reviewed; 108 AA.
AC P69734; P05874; P11264;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 02-JUN-2021, entry version 51.
DE RecName: Full=Protein Rev;
DE AltName: Full=Regulator of expression of viral proteins;
GN Name=rev;
OS Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian
OS immunodeficiency virus rhesus monkey).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11736;
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3646094; DOI=10.1016/0092-8674(87)90283-2;
RA Hirsch V., Riedel N., Mullins J.I.;
RT "The genome organization of STLV-3 is similar to that of the AIDS virus
RT except for a truncated transmembrane protein.";
RL Cell 49:307-319(1987).
CC -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC (late transcripts) out of the nucleus of infected cells. These pre-
CC mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC located in the env gene, that is not present in fully spliced viral
CC mRNAs (early transcripts). This function is essential since most viral
CC proteins are translated from unspliced or partially spliced pre-mRNAs
CC which cannot exit the nucleus by the pathway used by fully processed
CC cellular mRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC essential for activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC Note=The presence of both nuclear import and nuclear export signals
CC leads to continuous shuttling between the nucleus and cytoplasm.
CC {ECO:0000250}.
CC -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC structure present in incompletely spliced viral pre-mRNAs. This region
CC also contains the NLS which mediates nuclear localization. These
CC overlapping functions prevent Rev bound to RRE from undesirable return
CC to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC the NES remains accessible (By similarity). {ECO:0000250}.
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DR EMBL; M19499; AAB59911.1; ALT_SEQ; Genomic_RNA.
DR PIR; B26737; VKLJS2.
DR SMR; P69734; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR InterPro; IPR000625; REV_protein.
DR Pfam; PF00424; REV; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; mRNA transport; RNA-binding; Transport.
FT CHAIN 1..108
FT /note="Protein Rev"
FT /id="PRO_0000085300"
FT REGION 16..25
FT /note="Homomultimerization"
FT /evidence="ECO:0000250"
FT REGION 83..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 33..49
FT /note="Nuclear localization signal and RNA-binding (RRE)"
FT /evidence="ECO:0000250"
FT MOTIF 70..82
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 108 AA; 12689 MW; 045026AA25CA0BF4 CRC64;
MSSHEREEEL RKRLRLIHLL HQTIDSYPTG PGTANQRRQR RRRWRRRWQQ LLALADRIYS
FPDPPTDTPL DLAIQQLQNL AIESIPDPPT NTPEALCDPT KDSRSPQD
