ID   REV_SIVSP               Reviewed;         100 AA.
AC   P19502;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   02-JUN-2021, entry version 83.
DE   RecName: Full=Protein Rev;
DE   AltName: Full=Regulator of expression of viral proteins;
GN   Name=rev;
OS   Simian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian
OS   immunodeficiency virus sooty mangabey monkey).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11738;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1971917; DOI=10.1038/345636a0;
RA   Dewhurst S., Embretson J.E., Anderson D.C., Mullins J.I., Fultz P.N.;
RT   "Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-
RT   PBj14.";
RL   Nature 345:636-640(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1503826; DOI=10.1089/aid.1992.8.1179;
RA   Dewhurst S., Embretson J.E., Fultz P.N., Mullins J.I.;
RT   "Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14:
RT   characterization and comparison to acutely pathogenic clones.";
RL   AIDS Res. Hum. Retroviruses 8:1179-1187(1992).
CC   -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs
CC       (late transcripts) out of the nucleus of infected cells. These pre-
CC       mRNAs carry a recognition sequence called Rev responsive element (RRE)
CC       located in the env gene, that is not present in fully spliced viral
CC       mRNAs (early transcripts). This function is essential since most viral
CC       proteins are translated from unspliced or partially spliced pre-mRNAs
CC       which cannot exit the nucleus by the pathway used by fully processed
CC       cellular mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is
CC       essential for activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus. Host cytoplasm.
CC       Note=The presence of both nuclear import and nuclear export signals
CC       leads to continuous shuttling between the nucleus and cytoplasm.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The RNA-binding motif binds to the RRE, a stem-and-loop
CC       structure present in incompletely spliced viral pre-mRNAs. This region
CC       also contains the NLS which mediates nuclear localization. These
CC       overlapping functions prevent Rev bound to RRE from undesirable return
CC       to the nucleus. When Rev binds the RRE, the NLS becomes masked while
CC       the NES remains accessible (By similarity). {ECO:0000250}.
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DR   EMBL; L03298; AAA47776.1; -; Genomic_RNA.
DR   EMBL; M31325; AAA47751.1; -; Genomic_RNA.
DR   SMR; P19502; -.
DR   Proteomes; UP000007221; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000625; REV_protein.
DR   Pfam; PF00424; REV; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; mRNA transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..100
FT                   /note="Protein Rev"
FT                   /id="PRO_0000085302"
FT   REGION          14..22
FT                   /note="Homomultimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          18..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           30..46
FT                   /note="Nuclear localization signal and RNA-binding (RRE)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           67..79
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  11707 MW;  86189EF3AD8D4CAB CRC64;
     MSSNEEELRR RLRLIHLLHQ TNPYPDGPGT ANQRRRRRRR WRQRWQQILA LADRIYSFPD
     PPVDTPLDLA IQQLQRLAIE ELPNPPASAP EPLKDAAESP