REX1B_HUMAN
ID REX1B_HUMAN Reviewed; 201 AA.
AC Q96EN9; E9PAS0; Q8NAX4; Q9NWI0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Required for excision 1-B domain-containing protein {ECO:0000305};
GN Name=REX1BD {ECO:0000312|HGNC:HGNC:26098};
GN Synonyms=C19orf60 {ECO:0000312|HGNC:HGNC:26098};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adipose tissue, and Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 7-179 (ISOFORM 3).
RC TISSUE=Colon, and Glioblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q96EN9; P78358: CTAG1B; NbExp=3; IntAct=EBI-745810, EBI-1188472;
CC Q96EN9; G5E9A7: DMWD; NbExp=3; IntAct=EBI-745810, EBI-10976677;
CC Q96EN9; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-745810, EBI-12593112;
CC Q96EN9; O14645: DNALI1; NbExp=3; IntAct=EBI-745810, EBI-395638;
CC Q96EN9; Q53GS7: GLE1; NbExp=3; IntAct=EBI-745810, EBI-1955541;
CC Q96EN9; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-745810, EBI-473189;
CC Q96EN9; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-745810, EBI-6398041;
CC Q96EN9; O14901: KLF11; NbExp=3; IntAct=EBI-745810, EBI-948266;
CC Q96EN9; P43364: MAGEA11; NbExp=3; IntAct=EBI-745810, EBI-739552;
CC Q96EN9; P43360: MAGEA6; NbExp=3; IntAct=EBI-745810, EBI-1045155;
CC Q96EN9; Q99750: MDFI; NbExp=6; IntAct=EBI-745810, EBI-724076;
CC Q96EN9; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-745810, EBI-2811583;
CC Q96EN9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-745810, EBI-5235340;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96EN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96EN9-2; Sequence=VSP_028325, VSP_028326;
CC Name=3;
CC IsoId=Q96EN9-3; Sequence=VSP_047493;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91400.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK000857; BAA91400.1; ALT_FRAME; mRNA.
DR EMBL; AK091925; BAC03773.1; -; mRNA.
DR EMBL; AC003112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84723.1; -; Genomic_DNA.
DR EMBL; BC012078; AAH12078.1; -; mRNA.
DR EMBL; BF344503; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42524.1; -. [Q96EN9-1]
DR CCDS; CCDS46019.1; -. [Q96EN9-3]
DR RefSeq; NP_001093888.1; NM_001100418.1. [Q96EN9-1]
DR RefSeq; NP_001093889.1; NM_001100419.1. [Q96EN9-3]
DR AlphaFoldDB; Q96EN9; -.
DR SMR; Q96EN9; -.
DR BioGRID; 120372; 20.
DR IntAct; Q96EN9; 23.
DR MINT; Q96EN9; -.
DR STRING; 9606.ENSP00000351422; -.
DR iPTMnet; Q96EN9; -.
DR PhosphoSitePlus; Q96EN9; -.
DR BioMuta; REX1BD; -.
DR DMDM; 74731590; -.
DR EPD; Q96EN9; -.
DR jPOST; Q96EN9; -.
DR MassIVE; Q96EN9; -.
DR MaxQB; Q96EN9; -.
DR PaxDb; Q96EN9; -.
DR PeptideAtlas; Q96EN9; -.
DR PRIDE; Q96EN9; -.
DR ProteomicsDB; 19068; -.
DR ProteomicsDB; 76427; -. [Q96EN9-1]
DR ProteomicsDB; 76428; -. [Q96EN9-2]
DR Antibodypedia; 51892; 7 antibodies from 6 providers.
DR DNASU; 55049; -.
DR Ensembl; ENST00000358607.11; ENSP00000351422.5; ENSG00000006015.18. [Q96EN9-1]
DR Ensembl; ENST00000450195.6; ENSP00000398467.1; ENSG00000006015.18. [Q96EN9-3]
DR GeneID; 55049; -.
DR KEGG; hsa:55049; -.
DR MANE-Select; ENST00000358607.11; ENSP00000351422.5; NM_001100418.2; NP_001093888.1.
DR UCSC; uc002njv.5; human. [Q96EN9-1]
DR CTD; 55049; -.
DR GeneCards; REX1BD; -.
DR HGNC; HGNC:26098; REX1BD.
DR HPA; ENSG00000006015; Low tissue specificity.
DR neXtProt; NX_Q96EN9; -.
DR OpenTargets; ENSG00000006015; -.
DR PharmGKB; PA162378719; -.
DR VEuPathDB; HostDB:ENSG00000006015; -.
DR eggNOG; ENOG502S01K; Eukaryota.
DR GeneTree; ENSGT00390000011631; -.
DR HOGENOM; CLU_103386_0_0_1; -.
DR InParanoid; Q96EN9; -.
DR OMA; MVPTDFK; -.
DR OrthoDB; 1471953at2759; -.
DR PhylomeDB; Q96EN9; -.
DR TreeFam; TF332536; -.
DR PathwayCommons; Q96EN9; -.
DR SignaLink; Q96EN9; -.
DR BioGRID-ORCS; 55049; 53 hits in 1055 CRISPR screens.
DR ChiTaRS; C19orf60; human.
DR GenomeRNAi; 55049; -.
DR Pharos; Q96EN9; Tdark.
DR PRO; PR:Q96EN9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96EN9; protein.
DR Bgee; ENSG00000006015; Expressed in apex of heart and 195 other tissues.
DR ExpressionAtlas; Q96EN9; baseline and differential.
DR Genevisible; Q96EN9; HS.
DR InterPro; IPR039491; REX1-B.
DR PANTHER; PTHR28309; PTHR28309; 2.
DR Pfam; PF14966; DNA_repr_REX1B; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..201
FT /note="Required for excision 1-B domain-containing protein"
FT /id="PRO_0000305285"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..61
FT /note="MITETAAEPTVPAVPAAEEATEARGREEPAWPWKDAPIRTLVQRIHQLQAER
FT AQGFRRLEE -> MGRGFRGTGSSPSRERPHSTSPLPDDSLFVASLSSPRAGVGLSRVP
FT LRESGSVLPTYQSSPLVSGDTSWGPFR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028325"
FT VAR_SEQ 62..83
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_047493"
FT VAR_SEQ 179..201
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028326"
SQ SEQUENCE 201 AA; 22599 MW; AFB04D5FABDA5571 CRC64;
MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA ERAQGFRRLE
EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY RSTVHGVTQA FAAASREVLA
VEAELGGPRR QPLLAGHVRS LQELEQTRLG TVALLQLMET PELAGQEDAV RMQQLKMKVI
KTMEAISEVL QDLRFDAESA E
