REX1_ENTFA
ID REX1_ENTFA Reviewed; 216 AA.
AC Q830Y0;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Redox-sensing transcriptional repressor Rex 1 {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex1 {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=EF_2638;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; AE016830; AAO82346.1; -; Genomic_DNA.
DR RefSeq; NP_816276.1; NC_004668.1.
DR RefSeq; WP_002356528.1; NZ_KE136528.1.
DR AlphaFoldDB; Q830Y0; -.
DR SMR; Q830Y0; -.
DR STRING; 226185.EF_2638; -.
DR EnsemblBacteria; AAO82346; AAO82346; EF_2638.
DR GeneID; 60894634; -.
DR KEGG; efa:EF2638; -.
DR PATRIC; fig|226185.45.peg.922; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_1_9; -.
DR OMA; HEQRKAG; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..216
FT /note="Redox-sensing transcriptional repressor Rex 1"
FT /id="PRO_0000097891"
FT DNA_BIND 16..55
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 90..95
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ SEQUENCE 216 AA; 24423 MW; 1A2BC47BC0B1541B CRC64;
MKDQVIPKAT ARRLPLYYRY LRMLHDTGKN KVSSTELSEA VQVDSATIRR DFSYFGELGK
RGYGYDVENL MNFFAKTLNE DELTNVALIG VGNLGSALLK YKFHQSNSIR VSCAFDVNED
IVGRIVDGIP VYPMEDMMEQ IRVQQIEVAI LTIPARKAQE VVNKLAEAGV KGILNFTAAR
LVAPPEVLIQ NVDLTNELQT LIYFLHHDNE LIDEEE