REX1_THEMA
ID REX1_THEMA Reviewed; 208 AA.
AC Q9WY16;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Redox-sensing transcriptional repressor Rex 1 {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex1 {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=TM_0169;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; AE000512; AAD35262.1; -; Genomic_DNA.
DR PIR; G72408; G72408.
DR RefSeq; NP_227984.1; NC_000853.1.
DR RefSeq; WP_004082798.1; NZ_CP011107.1.
DR PDB; 5ZZ5; X-ray; 2.00 A; A/B/C/D=1-208.
DR PDB; 5ZZ6; X-ray; 2.20 A; A/B/C/D=1-208.
DR PDB; 5ZZ7; X-ray; 2.45 A; A/B=1-208.
DR PDB; 7WB3; X-ray; 2.40 A; A/B=1-208.
DR PDBsum; 5ZZ5; -.
DR PDBsum; 5ZZ6; -.
DR PDBsum; 5ZZ7; -.
DR PDBsum; 7WB3; -.
DR AlphaFoldDB; Q9WY16; -.
DR SMR; Q9WY16; -.
DR STRING; 243274.THEMA_03955; -.
DR EnsemblBacteria; AAD35262; AAD35262; TM_0169.
DR KEGG; tma:TM0169; -.
DR eggNOG; COG2344; Bacteria.
DR InParanoid; Q9WY16; -.
DR OMA; HEQRKAG; -.
DR OrthoDB; 1872374at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..208
FT /note="Redox-sensing transcriptional repressor Rex 1"
FT /id="PRO_0000097926"
FT DNA_BIND 15..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 89..94
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT HELIX 10..26
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 33..40
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 44..51
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 52..58
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 66..77
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 83..88
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 92..98
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 101..105
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 108..116
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT TURN 118..122
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 123..126
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 129..133
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 134..136
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 137..143
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 148..151
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 155..167
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 172..175
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT STRAND 187..189
FT /evidence="ECO:0007829|PDB:5ZZ5"
FT HELIX 192..206
FT /evidence="ECO:0007829|PDB:5ZZ5"
SQ SEQUENCE 208 AA; 22954 MW; B6A2627B60D10A83 CRC64;
MAEKIPKPVS KRLVSYYMCL ERLLDEGVEV VSSEELARRL DLKASQIRKD LSYFGEFGKR
GVGYNVEHLY DAIGEILGVK KEWKLVVVGA GNIGRAVANY TVMKEKGFRI IGIFDSDPSK
IGKEAAPGLT VSDVSELEKF VEEHGVEIGV IAVPAEHAQE IAERLEKAGI KGILNFAPVK
IKVSVPVENI DITASLRVLT FEIVRRNS
