ID   REX2_ENTFA              Reviewed;         215 AA.
AC   Q82ZW4;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex 2 {ECO:0000255|HAMAP-Rule:MF_01131};
GN   Name=rex2 {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=EF_2933;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; AE016830; AAO82621.1; -; Genomic_DNA.
DR   RefSeq; NP_816551.1; NC_004668.1.
DR   RefSeq; WP_002365189.1; NZ_KE136524.1.
DR   AlphaFoldDB; Q82ZW4; -.
DR   SMR; Q82ZW4; -.
DR   STRING; 226185.EF_2933; -.
DR   EnsemblBacteria; AAO82621; AAO82621; EF_2933.
DR   GeneID; 60894857; -.
DR   KEGG; efa:EF2933; -.
DR   PATRIC; fig|226185.45.peg.642; -.
DR   eggNOG; COG2344; Bacteria.
DR   HOGENOM; CLU_061534_1_1_9; -.
DR   OMA; GKPKVGY; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..215
FT                   /note="Redox-sensing transcriptional repressor Rex 2"
FT                   /id="PRO_0000097892"
FT   DNA_BIND        15..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   BINDING         89..94
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   215 AA;  23920 MW;  B6934FF718A6F4CD CRC64;
     MEKKMPKATA KRLPVYLRYL KMLGDSGVKR IKSREFSEMI QIPSATIRRD FSHVGELGRS
     GYGYDVPYLI EVFSNILNTQ EEKRIALIGC GNLGKALLKN NFRRNENLNI VCAFDNDSAL
     VGTTINGLLV HDMSELEAFV RQEGVTVAIS TVPSHHAQKA IDKIVQAGVT AILNFAPDRV
     SVPANVSVQY IDLTTELQTL IYFNETFSLA NSPKQ