REX2_THEMA
ID REX2_THEMA Reviewed; 204 AA.
AC Q9X1E1;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Redox-sensing transcriptional repressor Rex 2;
GN Name=rex2; OrderedLocusNames=TM_1427;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000305}.
CC -!- CAUTION: This protein lacks the conserved Gly residues in positions 90
CC and 93 that are potentially involved in NAD(H) binding. They are
CC replaced by an Asn and an Ala, respectively. {ECO:0000305}.
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DR EMBL; AE000512; AAD36497.1; -; Genomic_DNA.
DR PIR; H72256; H72256.
DR RefSeq; NP_229227.1; NC_000853.1.
DR RefSeq; WP_004081679.1; NZ_CP011107.1.
DR AlphaFoldDB; Q9X1E1; -.
DR SMR; Q9X1E1; -.
DR STRING; 243274.THEMA_07180; -.
DR EnsemblBacteria; AAD36497; AAD36497; TM_1427.
DR KEGG; tma:TM1427; -.
DR eggNOG; COG2344; Bacteria.
DR InParanoid; Q9X1E1; -.
DR OMA; GKPKVGY; -.
DR OrthoDB; 1872374at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..204
FT /note="Redox-sensing transcriptional repressor Rex 2"
FT /id="PRO_0000097927"
FT DNA_BIND 17..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 23187 MW; E5F3F86F97FD2D9C CRC64;
MAEMIHLPRS TFERLKMYRK VLEATKKPYI SSDEIARFLE INPDLVRKDF SYLNCQGKPR
VGYDVEELRK ELDDLFGVNN TTNMIIVGAN DLARALLSLD FSKAGVKVVA VFDTERENVG
KFIGEFAVRE LDVLERVIRR FDAEIAALCV SKDRAQATAE FLIEKGIKAV WNFTGVHLDL
PEGVIVVEED LTQSLLTIKH LLKK
