ID   REXB_LAMBD              Reviewed;         144 AA.
AC   P03759;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   12-AUG-2020, entry version 76.
DE   RecName: Full=Protein rexB;
GN   Name=rexB; OrderedLocusNames=lambdap53;
OS   Escherichia phage lambda (Bacteriophage lambda).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Lambdavirus.
OX   NCBI_TaxID=10710;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6221115; DOI=10.1016/0022-2836(82)90546-0;
RA   Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage lambda DNA.";
RL   J. Mol. Biol. 162:729-773(1982).
RN   [2]
RP   FUNCTION.
RX   PubMed=1828888; DOI=10.1073/pnas.88.11.4996;
RA   Schoulaker-Schwarz R., Dekel-Gorodetsky L., Engelberg-Kulka H.;
RT   "An additional function for bacteriophage lambda rex: the rexB product
RT   prevents degradation of the lambda O protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:4996-5000(1991).
RN   [3]
RP   FUNCTION.
RX   PubMed=9860994; DOI=10.1073/pnas.95.26.15481;
RA   Engelberg-Kulka H., Reches M., Narasimhan S., Schoulaker-Schwarz R.,
RA   Klemes Y., Aizenman E., Glaser G.;
RT   "rexB of bacteriophage lambda is an anti-cell death gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:15481-15486(1998).
RN   [4]
RP   TOPOLOGY.
RX   PubMed=1372278; DOI=10.1101/gad.6.3.497;
RA   Parma D.H., Snyder M., Sobolevski S., Nawroz M., Brody E., Gold L.;
RT   "The Rex system of bacteriophage lambda: tolerance and altruistic cell
RT   death.";
RL   Genes Dev. 6:497-510(1992).
CC   -!- FUNCTION: May participate in viral genome replication by preventing the
CC       degradation of lambda-O protein (protein playing a role in DNA
CC       replication). May also prevent host cell death under conditions of
CC       nutrient starvation. {ECO:0000269|PubMed:1828888,
CC       ECO:0000269|PubMed:9860994}.
CC   -!- SUBCELLULAR LOCATION: Host membrane; Multi-pass membrane protein.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; J02459; AAA96579.1; -; Genomic_DNA.
DR   PIR; D43010; IMBPBL.
DR   RefSeq; NP_040626.1; NC_001416.1.
DR   IntAct; P03759; 4.
DR   GeneID; 2703493; -.
DR   KEGG; vg:2703493; -.
DR   Proteomes; UP000001711; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031892; RexB.
DR   Pfam; PF15968; RexB; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..144
FT                   /note="Protein rexB"
FT                   /id="PRO_0000077708"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:1372278"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        27..46
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305|PubMed:1372278"
FT   TRANSMEM        47..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        66..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:1372278"
FT   TRANSMEM        86..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        105..115
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305|PubMed:1372278"
FT   TRANSMEM        116..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        135..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:1372278"
SQ   SEQUENCE   144 AA;  15967 MW;  6EAF23A85EF60CE4 CRC64;
     MRNRIMPGVY IVIIPYVIVS ICYLLFRHYI PGVSFSAHRD GLGATLSSYA GTMIAILIAA
     LTFLIGSRTR RLAKIREYGY MTSVVIVYAL SFVELGALFF CGLLLLSSIS GYMIPTIAIG
     IASASFIHIC ILVFQLYNLT REQE