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REXO1_MOUSE
ID   REXO1_MOUSE             Reviewed;        1213 AA.
AC   Q7TT28; Q3UMP1; Q69ZR0; Q6NSQ6; Q6PI95; Q9DA29;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=RNA exonuclease 1 homolog;
DE            EC=3.1.-.-;
DE   AltName: Full=Transcription elongation factor B polypeptide 3-binding protein 1;
GN   Name=Rexo1; Synonyms=Kiaa1138, Tceb3bp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Fetal brain;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J, and Czech II; TISSUE=Lung, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-279; SER-353 AND
RP   SER-514, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Seems to have no detectable effect on transcription
CC       elongation in vitro. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TCEA2 and ELOA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7TT28-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7TT28-2; Sequence=VSP_019121, VSP_019122, VSP_019123;
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD32386.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK173108; BAD32386.1; ALT_INIT; mRNA.
DR   EMBL; AK006228; BAB24471.1; -; mRNA.
DR   EMBL; AK144769; BAE26057.1; -; mRNA.
DR   EMBL; BC039623; AAH39623.1; -; mRNA.
DR   EMBL; BC052424; AAH52424.1; -; mRNA.
DR   EMBL; BC069964; AAH69964.1; -; mRNA.
DR   CCDS; CCDS24025.1; -. [Q7TT28-1]
DR   RefSeq; NP_080128.2; NM_025852.3. [Q7TT28-1]
DR   AlphaFoldDB; Q7TT28; -.
DR   SMR; Q7TT28; -.
DR   BioGRID; 211819; 1.
DR   IntAct; Q7TT28; 1.
DR   STRING; 10090.ENSMUSP00000049705; -.
DR   iPTMnet; Q7TT28; -.
DR   PhosphoSitePlus; Q7TT28; -.
DR   EPD; Q7TT28; -.
DR   jPOST; Q7TT28; -.
DR   MaxQB; Q7TT28; -.
DR   PaxDb; Q7TT28; -.
DR   PeptideAtlas; Q7TT28; -.
DR   PRIDE; Q7TT28; -.
DR   ProteomicsDB; 255238; -. [Q7TT28-1]
DR   ProteomicsDB; 255239; -. [Q7TT28-2]
DR   Antibodypedia; 22810; 183 antibodies from 27 providers.
DR   DNASU; 66932; -.
DR   Ensembl; ENSMUST00000057910; ENSMUSP00000049705; ENSMUSG00000047417. [Q7TT28-1]
DR   GeneID; 66932; -.
DR   KEGG; mmu:66932; -.
DR   UCSC; uc007gdq.1; mouse. [Q7TT28-2]
DR   UCSC; uc007gds.1; mouse. [Q7TT28-1]
DR   CTD; 57455; -.
DR   MGI; MGI:1914182; Rexo1.
DR   VEuPathDB; HostDB:ENSMUSG00000047417; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   GeneTree; ENSGT00940000158590; -.
DR   HOGENOM; CLU_006810_2_1_1; -.
DR   InParanoid; Q7TT28; -.
DR   OMA; YKRPTPQ; -.
DR   OrthoDB; 227856at2759; -.
DR   PhylomeDB; Q7TT28; -.
DR   TreeFam; TF350172; -.
DR   BioGRID-ORCS; 66932; 8 hits in 70 CRISPR screens.
DR   ChiTaRS; Rexo1; mouse.
DR   PRO; PR:Q7TT28; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q7TT28; protein.
DR   Bgee; ENSMUSG00000047417; Expressed in undifferentiated genital tubercle and 251 other tissues.
DR   ExpressionAtlas; Q7TT28; baseline and differential.
DR   Genevisible; Q7TT28; MM.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR031736; EloA-BP1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF15870; EloA-BP1; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Exonuclease; Hydrolase; Methylation;
KW   Nuclease; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1213
FT                   /note="RNA exonuclease 1 homolog"
FT                   /id="PRO_0000239233"
FT   DOMAIN          1052..1201
FT                   /note="Exonuclease"
FT   REGION          38..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          83..112
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        236..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..323
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..416
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..510
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..641
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..781
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         181
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N1G1"
FT   MOD_RES         277
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         279
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         353
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         487
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N1G1"
FT   MOD_RES         514
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         906
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N1G1"
FT   VAR_SEQ         1..679
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019121"
FT   VAR_SEQ         680..735
FT                   /note="PTAQEVCYRRAQLAQRDSASWLQAAPRPTERLSSVHISAPGEKRRIAHVPNP
FT                   RLAA -> MSFHTPSPVPRPPLRCEMRVLLTLNDRSFLVLRSSVMGLLSSCTHVPCPPS
FT                   A (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019122"
FT   VAR_SEQ         875..876
FT                   /note="SK -> STFLYFLLE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019123"
FT   CONFLICT        187
FT                   /note="G -> S (in Ref. 3; AAH69964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        284
FT                   /note="T -> A (in Ref. 3; AAH69964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        347
FT                   /note="S -> P (in Ref. 3; AAH69964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        394
FT                   /note="E -> K (in Ref. 3; AAH39623/AAH69964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        569
FT                   /note="P -> L (in Ref. 1; BAD32386)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1213 AA;  130790 MW;  2ECFAAA7A1B54363 CRC64;
     MLRSTGFFRS IDCPYWAGAP GGPCRRPYCH FRHRGARGPG APGSGGAASP ASGLGYDPYN
     PELPQPPVQR ENGALGQGDG MLELELVNQA IEAVRGEVEL EQRRYQELLE TARGHSAGPS
     ALAPCSPATS IDDDDTFSLA LTYTPGGLLS PDAAYQPTPL AVPAEPGHKY SLAPSDRSQG
     RAAGGAGALE YVPKAVGQPR RCGRPVSGGK YVVDSSKPST DLEYDPLSNY SARHLGRASA
     RDERATKRPR GSRGAEPYTP ALKKPCDPFG GCEARFSDSE DDVTSPPKAD VSSPKAGADP
     ESKAPGKPVS KEGREHEDGG LRGTKEMAVQ YDVEDLGQPP KAPDTVSVVK PGSPARASQD
     ARVPKEGKAK KKKSGTSASL SHKDKVRKKD KKKEKDPARP RGKEKVCTDK KKLPASNPRG
     KAQGPEGTKK KPSSATTVAS SGKGGSGRPS STGPQDSGPG PHAPLAWKAG SAKKMSSGKL
     VERKARSLDE GAPQDTPKLK KRALSHAELF GDESEEEDSS LGAGAPRVWP PTLPSLSSDS
     ESDSDSSLGL DETKVPKRLK AAPPASPVPP SPLSSSSSSS GASQCAEEDV DYSALEKEVD
     FDVDPMEECL RIFNESTSVK TEDKGRLARQ PPKEKAEEKT HAGLTTLFPG QKRRVSHLCK
     PGKESEAPKR TPVAPPARPP TAQEVCYRRA QLAQRDSASW LQAAPRPTER LSSVHISAPG
     EKRRIAHVPN PRLAAAPTGA KRALSASSSQ ASHGPEPGSQ PLKTRTLSGM ASKTTTTVTP
     KRIAHSPSLQ SLKKPVIPKE FGGKVPTVVR QRYLNLFIEE CLKFCSSNQE AIEKALNEEK
     VAYDRSPSKN IYLNVAVNTL KKLRGLVPNT VPNLSKASGR RVVSHEVVLG GKLAAKTSFS
     LSRPSSPRVE ELKGTALYSR LREYLLTQEQ LKENGYPFPH PERPGGAIIF TAEEKKPKDP
     SCRICCRCGT EYLVSSSGRC VRSEECYYHW GRLRRNRVAG GWETQYMCCS AAVGSVGCQV
     AKQHVQDGRK ENLEGFVRTF QKELPEDAHA GVFALDCEMS YTTYGLELTR VTVVDTDMQV
     VYDTFVKPDN EVVDYNTRFS GVTEADLVDT SITLRDVQAV LLSMFSADTI LIGHSLESDL
     LALKVIHGTV VDTSVLFPHR LGLPYKRSLR NLMADYLRQI IQDNVDGHSS SEDASACMHL
     VIWKIREDAK TKR
 
 
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