REXO3_ASHGO
ID REXO3_ASHGO Reviewed; 382 AA.
AC Q750A5;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=RNA exonuclease 3;
DE EC=3.1.-.-;
GN Name=REX3; OrderedLocusNames=AGR052C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54541.1; -; Genomic_DNA.
DR RefSeq; NP_986717.1; NM_211779.1.
DR AlphaFoldDB; Q750A5; -.
DR SMR; Q750A5; -.
DR STRING; 33169.AAS54541; -.
DR EnsemblFungi; AAS54541; AAS54541; AGOS_AGR052C.
DR GeneID; 4623018; -.
DR KEGG; ago:AGOS_AGR052C; -.
DR eggNOG; KOG2248; Eukaryota.
DR HOGENOM; CLU_022453_5_4_1; -.
DR InParanoid; Q750A5; -.
DR OMA; IDCEMGF; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0034476; P:U5 snRNA 3'-end processing; IEA:EnsemblFungi.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW rRNA processing.
FT CHAIN 1..382
FT /note="RNA exonuclease 3"
FT /id="PRO_0000120929"
FT DOMAIN 223..369
FT /note="Exonuclease"
SQ SEQUENCE 382 AA; 43398 MW; 15FFBD317F6D9747 CRC64;
MAVLRPVDMR MQPAPYEGRM KVIHKILEQL QKYRPRKANL EGLAVQWEHE VAKRSSSKHG
YMFNASLLLR DIARHKGNLN RQGRYEAPAP QVSKAEVLAA LRNLVLSEQV LSENGYVTAQ
DALESAAEEK EGLETCVRCL KKFDVRDIMV PTQCQFHVLK EQYNKDMRTF QYRCCGEIGT
SCTPFALGCK TLEHHVFRPC TYAAMSKLLP FRNTRGVEGE TNVLALDCEM AYTSCGYELI
RLTVVEFWTN AVLFDEIVQP LGEIIDLNTQ FSGVHEIDRA VAKTFEEARE VFLSPAMINE
NSILIGHGLE NDLNVLRIIH DKIIDTAILY PNGKFKSSLR NLAFQELSRR IQTGEHDSSE
DAIAAMDVVK HKLGIPLDRK TW