ID   REXO3_ASPFU             Reviewed;         645 AA.
AC   Q4WYA1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=rex3; ORFNames=AFUA_3G12310;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92352.1; -; Genomic_DNA.
DR   RefSeq; XP_754390.1; XM_749297.1.
DR   AlphaFoldDB; Q4WYA1; -.
DR   SMR; Q4WYA1; -.
DR   STRING; 746128.CADAFUBP00003607; -.
DR   PRIDE; Q4WYA1; -.
DR   EnsemblFungi; EAL92352; EAL92352; AFUA_3G12310.
DR   GeneID; 3512300; -.
DR   KEGG; afm:AFUA_3G12310; -.
DR   VEuPathDB; FungiDB:Afu3g12310; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_4_0_1; -.
DR   InParanoid; Q4WYA1; -.
DR   OMA; LNARYYK; -.
DR   OrthoDB; 774159at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..645
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120930"
FT   DOMAIN          421..601
FT                   /note="Exonuclease"
FT   REGION          49..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          611..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   645 AA;  70517 MW;  176E48DAA4727CA3 CRC64;
     MFAPLGLFKD VPCPEGQQCS LLTCIFSHDP LSPSLVNPSN VQGTLVAPEE AYESGPPPKK
     PRLETPPKTA GGKAQSLSEP RMESIESAPA PKAVRGSGLE QTTRTASQLQ SMTREVSPPT
     LQKESSAKKH APPAATEGEA HLPPRRAPRE SLNPRMLPKA PAAHGVRLSI LTKLHAAMCA
     LNEKLAKEEG STDNPLVLSP NELVTMALDE EEKAAKDNPS IYANVIKLRI VKLPKLSLEE
     WKKEVKAHLN ERYYKIEPTQ RTAEQKTLET GLSPKEEIAI ASKLITPLEG LEQYGYVTRK
     PTKEEVENAR RGVSESKGWE KCDRCGGRFQ VFPGRREDGS LTTGGQCTYH PGKPYYPPRR
     QTDHITGARD AYFPCCNESI GTSSGCTKGN THVFKVSESK RLASILQFEE TPTQADKGPQ
     QPVCFDCEMG YTTLGLELIR LTAVSWPQGK LLLDILVRPM GEILDLNSRF SGVFPEHYQK
     AIPYKSTSSP STTGDGALQV VESPAAARAL LFKFLQPDTP LIGHAIDNDL NACRIIHPTI
     IDTVLLYPHP RGLPIRMGLK ALVKKYLDRD IQTKGSQGHD SKEDAIATGD LVRVKAAETW
     KILKSKGWRI EGSKLIPPPG AKGASEDSKL GPGAGHKRKD TEVMP