ID   REXO3_CANAL             Reviewed;         404 AA.
AC   Q5AL29; A0A1D8PFK3; Q5ALF4;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=REX3; OrderedLocusNames=CAALFM_C113200CA;
GN   ORFNames=CaO19.12413, CaO19.4948;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26928.1; -; Genomic_DNA.
DR   RefSeq; XP_722159.2; XM_717066.2.
DR   AlphaFoldDB; Q5AL29; -.
DR   SMR; Q5AL29; -.
DR   STRING; 237561.Q5AL29; -.
DR   GeneID; 3636164; -.
DR   KEGG; cal:CAALFM_C113200CA; -.
DR   CGD; CAL0000199313; REX3.
DR   VEuPathDB; FungiDB:C1_13200C_A; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_5_4_1; -.
DR   InParanoid; Q5AL29; -.
DR   OrthoDB; 774159at2759; -.
DR   PRO; PR:Q5AL29; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..404
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120931"
FT   DOMAIN          241..389
FT                   /note="Exonuclease"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  46561 MW;  A27B17FA27358485 CRC64;
     MNNNAQNKRS LDDSNGNDTK RPKQEDPKYI LPKQVNTYPA TLPERKKNIE YILNILTKKQ
     PNITNPKLKA IDIEYEIAKK STNATYKTVF RQEVFKLTKP TKSPSQLSPQ QEHLKKLDQE
     AKELKILKEM VVSRKTLIAF GYIMEPPESI PNEKITRICN RCGTEFRLDQ QLQPIVCEFH
     HGKKQRGKYI CCMSNVDGQP CSKAKNHVYL LNTPEEKQAL LPYQFTKELF TTTSTKSKSR
     VLGIDCEMGF TTKGFELMRI TAIDYFTSKT VLDIFIKPIG EIVDFNTRYS GIHELTDDFL
     SWEQSMEKLG EIMDSETILI GHGLENDMNA MRLIHENIID TSILFPNKWK TGPTRRWSLK
     DLAFEFLSRR IQTGEHDSCE DSIAAIDIVK YFVKKRLQSI GSSS