ID   REXO3_CANGA             Reviewed;         398 AA.
AC   Q6FIU7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=REX3; OrderedLocusNames=CAGL0M11638g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62827.1; -; Genomic_DNA.
DR   RefSeq; XP_449847.1; XM_449847.1.
DR   AlphaFoldDB; Q6FIU7; -.
DR   SMR; Q6FIU7; -.
DR   STRING; 5478.XP_449847.1; -.
DR   EnsemblFungi; CAG62827; CAG62827; CAGL0M11638g.
DR   GeneID; 2891241; -.
DR   KEGG; cgr:CAGL0M11638g; -.
DR   CGD; CAL0137317; CAGL0M11638g.
DR   VEuPathDB; FungiDB:CAGL0M11638g; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_5_4_1; -.
DR   InParanoid; Q6FIU7; -.
DR   OMA; IDCEMGF; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0034476; P:U5 snRNA 3'-end processing; IEA:EnsemblFungi.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..398
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120932"
FT   DOMAIN          239..385
FT                   /note="Exonuclease"
SQ   SEQUENCE   398 AA;  45388 MW;  EBB278975D5943CD CRC64;
     MMGKETPSLR PVELPIQPVG FQDRYKVIHK ICEALEKVAY PRVKLAKFAV SLELKLAKES
     KTSQLYRFNV GILLRDIVKF KANVYKLKIA NKPLVPQKVN GRSHTAPITT KQEVFTRLRE
     LLIDKETLRK NGYILPDVKY EPQQPVSSHV TCVRCGTKFS KEDIMNSVVC KFHPSKKLYD
     KSTKLEIYPC CGESTSSVSF LRLGCSTQKH HVYKGETYSE LCTIANFLTT DLIDGKENVL
     ALDCEMGFTT MGYEMVRLTI VDFFTSKTLY DEIIRPIGEV IDLNTQFSGV REEDILYAKD
     YEDVMEDVLR ADMINRNSIL IGHGLENDLN VMRLFHTRIL DTAIMYSVGR FKNSLKNLSF
     EILSRKIQLG EHDSSQDAIA AMDIIKAKNG ISITQTDW