ID   REXO3_EMENI             Reviewed;         638 AA.
AC   Q5B367; C8V8L1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=rex3; ORFNames=AN5013;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA61091.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000084; EAA61091.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001303; CBF76279.1; -; Genomic_DNA.
DR   RefSeq; XP_662617.1; XM_657525.1.
DR   AlphaFoldDB; Q5B367; -.
DR   SMR; Q5B367; -.
DR   STRING; 162425.CADANIAP00005379; -.
DR   PRIDE; Q5B367; -.
DR   EnsemblFungi; CBF76279; CBF76279; ANIA_05013.
DR   EnsemblFungi; EAA61091; EAA61091; AN5013.2.
DR   GeneID; 2872816; -.
DR   KEGG; ani:AN5013.2; -.
DR   VEuPathDB; FungiDB:AN5013; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_4_0_1; -.
DR   InParanoid; Q5B367; -.
DR   OMA; LNARYYK; -.
DR   OrthoDB; 774159at2759; -.
DR   Proteomes; UP000000560; Chromosome III.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..638
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120933"
FT   DOMAIN          408..584
FT                   /note="Exonuclease"
FT   REGION          37..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  70178 MW;  D45840C5DB5706DA CRC64;
     MFAPLGLFRD IPCPQREECS LIACLFSHRD LNSAPAAQDQ VLEQKEPAKL PPKRLKLEPR
     PEAKETPKDD LRHVSDSGRS TPVKKTTAPA TNAENISPVS RQPNIPKNTA TAPIKRELNA
     NTGSSIPPRR APKEALNPRM IQKSPATYNV RMAILKKLHG TLCSLNDQLA KDKALEDKCL
     ILTPDELITM ALDEEEKVAK ESPTVYSNVV KLRIVKLSRM SKEDWAKELK DYLNKKYYKI
     KAEPVQKEPK PFKTDLSVEE EIAVASQLIT PLQGLEDFGY VTRVPTAEEI EIAKRGVAEA
     KGWEKCERCN ARFQVFPGRR EDGTLTSGGT CTYHPGKSFY PPRKKTDHIT GTMREGYFTC
     CNQKLGESSG CTTGATHVYK VSETKRLASI LQFEKTPENP DLHNPTPICF DCEMGYTTLG
     MELIRLTAVS WPEGKKVLDV LVRPLGEVLD LNSRFSGVFP EHYTNALPYS TAPTKSSAPS
     SSSPSQLQLV SSPAAARTLL FNLLTPSTPL IGHAIDNDLN ACRIIHPTVI DTAILYPHPG
     GGLPYRMSLR TLAKKHLDRE IQTGGASGKQ GHDSVEDALA TGDLVRVKAG LVWGRLKEKG
     WIVEEGRLVA PDSSSNTVSM QTKLGEGAGA KRAREGTS