ID   REXO3_KLULA             Reviewed;         478 AA.
AC   Q6CJB5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=REX3; OrderedLocusNames=KLLA0F19910g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98682.1; -; Genomic_DNA.
DR   RefSeq; XP_455974.1; XM_455974.1.
DR   AlphaFoldDB; Q6CJB5; -.
DR   SMR; Q6CJB5; -.
DR   STRING; 28985.XP_455974.1; -.
DR   EnsemblFungi; CAG98682; CAG98682; KLLA0_F19910g.
DR   GeneID; 2895510; -.
DR   KEGG; kla:KLLA0_F19910g; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_5_4_1; -.
DR   InParanoid; Q6CJB5; -.
DR   OMA; IDCEMGF; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0034476; P:U5 snRNA 3'-end processing; IEA:EnsemblFungi.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..478
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120934"
FT   DOMAIN          320..465
FT                   /note="Exonuclease"
SQ   SEQUENCE   478 AA;  54958 MW;  05F1C32C52014E87 CRC64;
     MYPTLNLAVC LKSSHLISSH RFCLKNSQST EKHQKEINIS VKERYTCNPS HRQKKNGWVR
     EKNALREPLT ASLKFTIHLN SIVFRYIPLY AIIMVGNPVL RPVDMKMQPA PYQDRVRVVQ
     KIYTQLKRFQ SSSPHIIKAS TIWEHEVAKI AKTRQSYAFN ASILLRDIVK YKGNLDKTGK
     PKNNSSSLIQ RSHVLQKLRS LLLDEETLSR NGFFVKMYDT DPINESESDY VECYRCETKF
     DVTKIMEPTV CRYHLQRKVY NRETKKREFP CCGASLESYS DISAGCMKAK NHVYKWENFT
     KLSSVVPFKS LVDIKGEENV LALDCEMAFT SKGYEMIRIT IVDFWSSEVV YDKVIKPLGE
     IIDLNSKFSG IHHIDDTAPT IHEAEKCYIC PSMINQNSIL IGHGLDNDLR VMRIVHDKVI
     DTAVLYPAGK YKSSLKNLSF EILSRRIQGG EHDSSEDAIA AMDVIKKKLS IPLDKKSW